+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain.
LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca2+. LRRC55 protein is also the only γ subunit of BK channels that is expressed...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5784982?pdf=render |
| _version_ | 1819031062493265920 |
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| author | Ying-Ying Zhang Xue Han Ye Liu Jian Chen Lei Hua Qian Ma Yang-Yu-Xin Huang Qiong-Yao Tang Zhe Zhang |
| author_facet | Ying-Ying Zhang Xue Han Ye Liu Jian Chen Lei Hua Qian Ma Yang-Yu-Xin Huang Qiong-Yao Tang Zhe Zhang |
| author_sort | Ying-Ying Zhang |
| collection | DOAJ |
| description | LRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca2+. LRRC55 protein is also the only γ subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions. |
| first_indexed | 2024-12-21T06:40:05Z |
| format | Article |
| id | doaj.art-f74cb16156bf434ba0b173c4c4b7f9a2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T06:40:05Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f74cb16156bf434ba0b173c4c4b7f9a22022-12-21T19:12:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01131e019174910.1371/journal.pone.0191749+mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain.Ying-Ying ZhangXue HanYe LiuJian ChenLei HuaQian MaYang-Yu-Xin HuangQiong-Yao TangZhe ZhangLRRC55 (leucine-rich repeat-containing protein 55) protein is an auxiliary γ subunit of BK (Big conductance potassium channel) channels, which leftward shifts GVs of BK channels around 50 mV in the absence of cytosolic Ca2+. LRRC55 protein is also the only γ subunit of BK channels that is expressed in mammalian nervous system. However, the expression pattern of LRRC55 gene in adult mammalian brain remains elusive. In this study, we investigated the distribution of LRRC55 mRNA in the adult mouse brain by using in situ hybridization. We found that LRRC55 mRNA is richly expressed in the adult mouse medial habenula nucleus (MHb), cerebellum and pons. However, the potential role of LRRC55 in MHb and cerebellum could be different based on the function of BK channels in these brain regions.http://europepmc.org/articles/PMC5784982?pdf=render |
| spellingShingle | Ying-Ying Zhang Xue Han Ye Liu Jian Chen Lei Hua Qian Ma Yang-Yu-Xin Huang Qiong-Yao Tang Zhe Zhang +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain. PLoS ONE |
| title | +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain. |
| title_full | +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain. |
| title_fullStr | +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain. |
| title_full_unstemmed | +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain. |
| title_short | +mRNA expression of LRRC55 protein (leucine-rich repeat-containing protein 55) in the adult mouse brain. |
| title_sort | mrna expression of lrrc55 protein leucine rich repeat containing protein 55 in the adult mouse brain |
| url | http://europepmc.org/articles/PMC5784982?pdf=render |
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