Autoimmune Thyroid Disease and Breast Cancer Prognosis
Objective:The association of breast cancer and thyroid autoimmunity has been suggested by many studies in the literature, but the causality still needed to be proven. With this study we aimed to search the correlation between thyroid autoimmunity and breast cancer prognostic factors.Materials and Me...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-04-01
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| Series: | European Journal of Breast Health |
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http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/autoimmune-thyroid-disease-and-breast-cancer-progn/42233
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| _version_ | 1797916193347076096 |
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| author | Tolga Özmen Bahadır Mahmut Güllüoğlu Cumhur Şevket Yegen Atilla Soran |
| author_facet | Tolga Özmen Bahadır Mahmut Güllüoğlu Cumhur Şevket Yegen Atilla Soran |
| author_sort | Tolga Özmen |
| collection | DOAJ |
| description | Objective:The association of breast cancer and thyroid autoimmunity has been suggested by many studies in the literature, but the causality still needed to be proven. With this study we aimed to search the correlation between thyroid autoimmunity and breast cancer prognostic factors.Materials and Methods:To this prospective cohort study 200 consecutive breast cancer patients, who were operated in our clinic were included. Patients’ serum thyroid hormone, anti-thyroglobuline (anti-TG) and antithyroid peroxidase (anti-TPO) levels and tumors’ prognostic parameters (tumor size, axillary involvement, histological grade, lymphovascular invasion, receptor status, Ki-67 proliferation index) were collected. The correlation between serum thyroid autoantibody levels and tumor’s prognostic factors were studied.Results:The prevalence of thyroid autoimmunity (high levels of serum anti-TPO and/or anti-TG) was 18.5% (n=37). Patients with thyroid autoimmunity had a significant lower rate of axillary involvement and a lower rate of Ki-67 proliferation index (22% vs. 46% [p=0,007] and 12.73% vs. 20.72% [p=0.025], respectively) and were more commonly included to the “low-risk” group (<14%) according to their Ki-67 scores (68% vs. 46%; p=0.015). Other parameters did not differ between the two groups.Conclusion:We found a favorable correlation between thyroid autoimmunity and axillary involvement and also Ki-67 proliferation index score, which are two crucial and strongly predictive parameters of breast cancer prognoses. This supports the idea of thyroid autoimmunity being a favorable prognostic parameter. Further studies are necessary to investigate the reasons of protective or predictive effect of high thyroid peroxidase levels in breast cancer patients. |
| first_indexed | 2024-04-10T12:53:20Z |
| format | Article |
| id | doaj.art-f74cee940df9480d89c72be6e5d793e0 |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T12:53:20Z |
| publishDate | 2015-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-f74cee940df9480d89c72be6e5d793e02023-02-15T16:13:39ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312015-04-01112677110.5152/tjbh.2015.246213049054Autoimmune Thyroid Disease and Breast Cancer PrognosisTolga Özmen0Bahadır Mahmut Güllüoğlu1Cumhur Şevket Yegen2Atilla Soran3 Marmara Üniversitesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Marmara Üniversitesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Marmara Üniversitesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Magee Womens Hospital of UPMC, Genel Cerrahi Anabilim Dalı, Pittsburgh, ABD Objective:The association of breast cancer and thyroid autoimmunity has been suggested by many studies in the literature, but the causality still needed to be proven. With this study we aimed to search the correlation between thyroid autoimmunity and breast cancer prognostic factors.Materials and Methods:To this prospective cohort study 200 consecutive breast cancer patients, who were operated in our clinic were included. Patients’ serum thyroid hormone, anti-thyroglobuline (anti-TG) and antithyroid peroxidase (anti-TPO) levels and tumors’ prognostic parameters (tumor size, axillary involvement, histological grade, lymphovascular invasion, receptor status, Ki-67 proliferation index) were collected. The correlation between serum thyroid autoantibody levels and tumor’s prognostic factors were studied.Results:The prevalence of thyroid autoimmunity (high levels of serum anti-TPO and/or anti-TG) was 18.5% (n=37). Patients with thyroid autoimmunity had a significant lower rate of axillary involvement and a lower rate of Ki-67 proliferation index (22% vs. 46% [p=0,007] and 12.73% vs. 20.72% [p=0.025], respectively) and were more commonly included to the “low-risk” group (<14%) according to their Ki-67 scores (68% vs. 46%; p=0.015). Other parameters did not differ between the two groups.Conclusion:We found a favorable correlation between thyroid autoimmunity and axillary involvement and also Ki-67 proliferation index score, which are two crucial and strongly predictive parameters of breast cancer prognoses. This supports the idea of thyroid autoimmunity being a favorable prognostic parameter. Further studies are necessary to investigate the reasons of protective or predictive effect of high thyroid peroxidase levels in breast cancer patients. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/autoimmune-thyroid-disease-and-breast-cancer-progn/42233 breast cancerautoimmune thyroid diseaseprognostic factors |
| spellingShingle | Tolga Özmen Bahadır Mahmut Güllüoğlu Cumhur Şevket Yegen Atilla Soran Autoimmune Thyroid Disease and Breast Cancer Prognosis European Journal of Breast Health breast cancer autoimmune thyroid disease prognostic factors |
| title | Autoimmune Thyroid Disease and Breast Cancer Prognosis |
| title_full | Autoimmune Thyroid Disease and Breast Cancer Prognosis |
| title_fullStr | Autoimmune Thyroid Disease and Breast Cancer Prognosis |
| title_full_unstemmed | Autoimmune Thyroid Disease and Breast Cancer Prognosis |
| title_short | Autoimmune Thyroid Disease and Breast Cancer Prognosis |
| title_sort | autoimmune thyroid disease and breast cancer prognosis |
| topic | breast cancer autoimmune thyroid disease prognostic factors |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/autoimmune-thyroid-disease-and-breast-cancer-progn/42233
|
| work_keys_str_mv | AT tolgaozmen autoimmunethyroiddiseaseandbreastcancerprognosis AT bahadırmahmutgulluoglu autoimmunethyroiddiseaseandbreastcancerprognosis AT cumhursevketyegen autoimmunethyroiddiseaseandbreastcancerprognosis AT atillasoran autoimmunethyroiddiseaseandbreastcancerprognosis |