Synergic effect of Eicosapentaenoic acid and Lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells
<p>Abstract</p> <p>Background</p> <p>PUFAs are potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, an enzyme catalyzing the conversion of HMGCoA to mevalonate, the rate limiting step in cholesterol biosynthesis. Statins represent a class of d...
Main Authors: | Miccolis Angelica, Tutino Valeria, Refolo Maria G, Messa Caterina, Notarnicola Maria, Caruso Maria G |
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Format: | Article |
Language: | English |
Published: |
BMC
2010-11-01
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Series: | Lipids in Health and Disease |
Online Access: | http://www.lipidworld.com/content/9/1/135 |
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