OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS
The data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statisti...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2012-02-01
|
| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/762 |
| _version_ | 1797237724708601856 |
|---|---|
| author | S. I. Kolesnikov A. V. Mashanov B. Ya. Vlasov G. G. Yushkov |
| author_facet | S. I. Kolesnikov A. V. Mashanov B. Ya. Vlasov G. G. Yushkov |
| author_sort | S. I. Kolesnikov |
| collection | DOAJ |
| description | The data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system. |
| first_indexed | 2024-03-08T12:23:47Z |
| format | Article |
| id | doaj.art-f74f2833d9e84be9a50e8957155496f2 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:24:18Z |
| publishDate | 2012-02-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-f74f2833d9e84be9a50e8957155496f22024-03-28T07:49:02ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-02-0101115119708OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDSS. I. Kolesnikov0A. V. Mashanov1B. Ya. Vlasov2G. G. Yushkov3Scientific Center of Family Health Problems and Human Reproduction SB RAMS, IrkutskScientific Research Institute of Biophysics of Angarsk State Technical Academy, AngarskScientific Center of Family Health Problems and Human Reproduction SB RAMS, IrkutskScientific Research Institute of Biophysics of Angarsk State Technical Academy, AngarskThe data on the expressed toxic effect of ethanol in dose DL50 (12 g/kg) on experimental rats were received. The toxic effect was expressed in significant stimulation of processes of lipid peroxidation against the background of antioxidant system suppression. While evaluating the results of statistic analysis it was proved, that new chelate zinc (2,8,9-trihydrozincatrane) in the protective dose of 4 mg/kg under conditions of the acute ethanol poisoning reduces the severity of oxidative stress and normalizes indicators of antioxidant system.https://www.actabiomedica.ru/jour/article/view/7622,8,9-тригидроцинкатран2,8,9-trihydrozincatraneacute ethanol poisoningalcohol dehydrogenase |
| spellingShingle | S. I. Kolesnikov A. V. Mashanov B. Ya. Vlasov G. G. Yushkov OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS Acta Biomedica Scientifica 2,8,9-тригидроцинкатран 2,8,9-trihydrozincatrane acute ethanol poisoning alcohol dehydrogenase |
| title | OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS |
| title_full | OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS |
| title_fullStr | OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS |
| title_full_unstemmed | OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS |
| title_short | OXIDATIVE STRESS AS A PATHOGENETIC LINK OF ACUTE ETHANOL POISONING AND ITS CORRECTION WITH CHELATE ZINC COMPOUNDS |
| title_sort | oxidative stress as a pathogenetic link of acute ethanol poisoning and its correction with chelate zinc compounds |
| topic | 2,8,9-тригидроцинкатран 2,8,9-trihydrozincatrane acute ethanol poisoning alcohol dehydrogenase |
| url | https://www.actabiomedica.ru/jour/article/view/762 |
| work_keys_str_mv | AT sikolesnikov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds AT avmashanov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds AT byavlasov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds AT ggyushkov oxidativestressasapathogeneticlinkofacuteethanolpoisoninganditscorrectionwithchelatezinccompounds |