Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus
Background: Lowbasal insulin level is a risk factor for Type 2Diabetes mellitus (T2DM)as a result of altered insulin sensitivity pattern. However, it is uncertain if exercise may influence the occurrence of T2DM in the offspring of diabetic parents. Objective: To assess the effect of exercise on...
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| Format: | Article |
| Language: | English |
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Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu
2019-12-01
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| Series: | Annals of Health Research |
| Subjects: | |
| Online Access: | http://www.annalsofhealthresearch.com/index.php/ahr/article/view/192 |
| _version_ | 1828413109324218368 |
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| author | Taiwo EO Sofola OA Fasanmade AA Onyemelukwe G |
| author_facet | Taiwo EO Sofola OA Fasanmade AA Onyemelukwe G |
| author_sort | Taiwo EO |
| collection | DOAJ |
| description | Background: Lowbasal insulin level is a risk factor for Type 2Diabetes mellitus (T2DM)as a result of altered insulin sensitivity pattern. However, it is uncertain if exercise may influence the occurrence of T2DM in the offspring of diabetic parents.
Objective: To assess the effect of exercise on basal insulin levels in the offspring of T2DM parents compared with the offspring of non-diabetic parents.
Design: The participants were assigned into four groups using a convenience sampling method; 27 Normal-weight Offspring of Non-Diabetic Parents (NONDP), 21 Normal-weight Offspring of Diabetic Parents (NODP), 26 Overweight Offspring of Non-Diabetic Parents (OONDP) and 21 Overweight Offspring of Diabetic Parents (OODP). Each participant followed a protocol of graded exercise using ''tummy trimmer'' everyday spending 30-45 minutes daily for 24 weeks. Blood samples were obtained after overnight fasting for determination of insulin level using standard methods(immunoassay technique) at baseline, six weeks, 12 weeks, 18 weeks and 24 weeks respectively.
Results: There were 23/42males (54.8%) in the study groups and 34/51 females (64.2%)in the control groups. Thirty-one (58.7%) in the control group and 24(57.1%) in the study group were aged 21-30 years. An increase in insulin levels was recorded at 12 weeks in all groups except in NONDP where the insulin levels decreased. The insulin level change was highest in the NODP (2.25ng/ml) group.
Conclusions: Graded exercise improved insulin levels in all test groups. The clinical importance of graded exercise in the prevention of diabetes mellitus among the offspring of diabetic parents may be promising. |
| first_indexed | 2024-12-10T13:01:23Z |
| format | Article |
| id | doaj.art-f75057174cea461da8916d77a6ac3083 |
| institution | Directory Open Access Journal |
| issn | 2476-8642 2536-6149 |
| language | English |
| last_indexed | 2024-12-10T13:01:23Z |
| publishDate | 2019-12-01 |
| publisher | Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu |
| record_format | Article |
| series | Annals of Health Research |
| spelling | doaj.art-f75057174cea461da8916d77a6ac30832022-12-22T01:47:57ZengMedical and Dental Consultants Association of Nigeria, OOUTH SagamuAnnals of Health Research2476-86422536-61492019-12-015222423010.30442/ahr.0502-24-54Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitusTaiwo EO0Sofola OA1Fasanmade AA2Onyemelukwe G3Department of Physiology, OlabisiOnabanjo University, Ago-Iwoye, Ogun State, NigeriaDepartment of Physiology, College of Medicine, University of Lagos, Idi-Araba, Lagos, NigeriaDepartment of Physiology, University of Ibadan, Ibadan, Oyo State, NigeriaDepartment of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, NigeriaBackground: Lowbasal insulin level is a risk factor for Type 2Diabetes mellitus (T2DM)as a result of altered insulin sensitivity pattern. However, it is uncertain if exercise may influence the occurrence of T2DM in the offspring of diabetic parents. Objective: To assess the effect of exercise on basal insulin levels in the offspring of T2DM parents compared with the offspring of non-diabetic parents. Design: The participants were assigned into four groups using a convenience sampling method; 27 Normal-weight Offspring of Non-Diabetic Parents (NONDP), 21 Normal-weight Offspring of Diabetic Parents (NODP), 26 Overweight Offspring of Non-Diabetic Parents (OONDP) and 21 Overweight Offspring of Diabetic Parents (OODP). Each participant followed a protocol of graded exercise using ''tummy trimmer'' everyday spending 30-45 minutes daily for 24 weeks. Blood samples were obtained after overnight fasting for determination of insulin level using standard methods(immunoassay technique) at baseline, six weeks, 12 weeks, 18 weeks and 24 weeks respectively. Results: There were 23/42males (54.8%) in the study groups and 34/51 females (64.2%)in the control groups. Thirty-one (58.7%) in the control group and 24(57.1%) in the study group were aged 21-30 years. An increase in insulin levels was recorded at 12 weeks in all groups except in NONDP where the insulin levels decreased. The insulin level change was highest in the NODP (2.25ng/ml) group. Conclusions: Graded exercise improved insulin levels in all test groups. The clinical importance of graded exercise in the prevention of diabetes mellitus among the offspring of diabetic parents may be promising.http://www.annalsofhealthresearch.com/index.php/ahr/article/view/192diabetes mellitusgraded exerciseinsulin levelsoffspring |
| spellingShingle | Taiwo EO Sofola OA Fasanmade AA Onyemelukwe G Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus Annals of Health Research diabetes mellitus graded exercise insulin levels offspring |
| title | Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus |
| title_full | Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus |
| title_fullStr | Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus |
| title_full_unstemmed | Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus |
| title_short | Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus |
| title_sort | effect of exercise on basal insulin levels in normoglycaemic offspring of patients with type 2 diabetes mellitus |
| topic | diabetes mellitus graded exercise insulin levels offspring |
| url | http://www.annalsofhealthresearch.com/index.php/ahr/article/view/192 |
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