Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method
Abstract Background Forearm autotransplantation after parathyroidectomy has turned into the standard method for secondary hyperparathyroidism (SHPT) treatment in chronic kidney disease patients. Our study aimed to explore the effects of three methods including muscle, subcutaneous and muscle + subcu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | BMC Surgery |
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| Online Access: | https://doi.org/10.1186/s12893-021-01222-2 |
| _version_ | 1818722427703656448 |
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| author | Bin Zhou Lei Zhu Cheng Xiang Feng Cheng Xi Zhu Yi Zhou Yong Wang |
| author_facet | Bin Zhou Lei Zhu Cheng Xiang Feng Cheng Xi Zhu Yi Zhou Yong Wang |
| author_sort | Bin Zhou |
| collection | DOAJ |
| description | Abstract Background Forearm autotransplantation after parathyroidectomy has turned into the standard method for secondary hyperparathyroidism (SHPT) treatment in chronic kidney disease patients. Our study aimed to explore the effects of three methods including muscle, subcutaneous and muscle + subcutaneous transplant methods on SHPT. Methods Seventy five SHPT patients were enrolled and assigned into the muscle + subcutaneous (M + S) (n = 26), muscle (M) (n = 35), and subcutaneous (S) (n = 14) groups. The operation efficacy evaluation included preoperative and postoperative biological characteristics such as parathyroid hormone (PTH), serum phosphorus, serum calcium and alkaline phosphatase (ALP). The data were recorded from pre-operation time point to 1, 2, 3, 6, 12, 18, 24 month (mo) postoperation periods. After operation, short-form health survey (SF-36) scores was made for life quality identification at 1, 2, 3, 6, 12, 24 time points. Symptoms about SHPT including bone pain, fracture, pruritus, and coronary artery calcification were followed-up based on the scale. Results Compared with the preoperative record, all the M + S, M, and S groups showed postoperative decreased levels of PTH, serum phosphorus, serum calcium, calcium-phosphorus. In M + S group, the PTH and serum calcium level kept more steady compared with the M and S groups during a 24 mo duration observation. After this, a SF-36 score scale which represents the life quality show M + S group got more scores at 3, 6, 12, 18 and 24 mo points. At last, the incidence of SHPT associated symptoms including Bone pain, Fracture, Pruritus, and Coronary artery calcification in M + S group were decreased compared with M and S groups at 1, 3, 6, 12 and 24 mo post-operation time points. Conclusion M + S seems to be an efficient method for medical treatment of SHPT patients in the control of PTH and serum calcium. This mixed transplant strategy improves the biochemical characterizes compared with M and S groups in SHPT patients. Furthermore, the M + S method make beneficial on clinical outcomes and life quality of patients. |
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| institution | Directory Open Access Journal |
| issn | 1471-2482 |
| language | English |
| last_indexed | 2024-12-17T20:54:27Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
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| series | BMC Surgery |
| spelling | doaj.art-f750a1bdc6384bbb9347fd44588b381b2022-12-21T21:32:55ZengBMCBMC Surgery1471-24822021-05-012111810.1186/s12893-021-01222-2Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous methodBin Zhou0Lei Zhu1Cheng Xiang2Feng Cheng3Xi Zhu4Yi Zhou5Yong Wang6Department of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University College of MedicineDepartment of Thyroid and Breast Surgery, Lishui Hospital of Zhejiang UniversityDepartment of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University College of MedicineDepartment of Thyroid and Breast Surgery, Lishui Hospital of Zhejiang UniversityDepartment of Thyroid and Breast Surgery, Lishui Hospital of Zhejiang UniversityDepartment of Thyroid and Breast Surgery, Lishui Hospital of Zhejiang UniversityDepartment of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University College of MedicineAbstract Background Forearm autotransplantation after parathyroidectomy has turned into the standard method for secondary hyperparathyroidism (SHPT) treatment in chronic kidney disease patients. Our study aimed to explore the effects of three methods including muscle, subcutaneous and muscle + subcutaneous transplant methods on SHPT. Methods Seventy five SHPT patients were enrolled and assigned into the muscle + subcutaneous (M + S) (n = 26), muscle (M) (n = 35), and subcutaneous (S) (n = 14) groups. The operation efficacy evaluation included preoperative and postoperative biological characteristics such as parathyroid hormone (PTH), serum phosphorus, serum calcium and alkaline phosphatase (ALP). The data were recorded from pre-operation time point to 1, 2, 3, 6, 12, 18, 24 month (mo) postoperation periods. After operation, short-form health survey (SF-36) scores was made for life quality identification at 1, 2, 3, 6, 12, 24 time points. Symptoms about SHPT including bone pain, fracture, pruritus, and coronary artery calcification were followed-up based on the scale. Results Compared with the preoperative record, all the M + S, M, and S groups showed postoperative decreased levels of PTH, serum phosphorus, serum calcium, calcium-phosphorus. In M + S group, the PTH and serum calcium level kept more steady compared with the M and S groups during a 24 mo duration observation. After this, a SF-36 score scale which represents the life quality show M + S group got more scores at 3, 6, 12, 18 and 24 mo points. At last, the incidence of SHPT associated symptoms including Bone pain, Fracture, Pruritus, and Coronary artery calcification in M + S group were decreased compared with M and S groups at 1, 3, 6, 12 and 24 mo post-operation time points. Conclusion M + S seems to be an efficient method for medical treatment of SHPT patients in the control of PTH and serum calcium. This mixed transplant strategy improves the biochemical characterizes compared with M and S groups in SHPT patients. Furthermore, the M + S method make beneficial on clinical outcomes and life quality of patients.https://doi.org/10.1186/s12893-021-01222-2Forearm autotransplantationSecondary hyperparathyroidismMuscle and subcutaneous transplantation |
| spellingShingle | Bin Zhou Lei Zhu Cheng Xiang Feng Cheng Xi Zhu Yi Zhou Yong Wang Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method BMC Surgery Forearm autotransplantation Secondary hyperparathyroidism Muscle and subcutaneous transplantation |
| title | Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method |
| title_full | Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method |
| title_fullStr | Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method |
| title_full_unstemmed | Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method |
| title_short | Total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients: analysis of muscle, subcutaneous and muscle + subcutaneous method |
| title_sort | total parathyroidectomy with forearm autotransplantation in secondary hyperparathyroidism patients analysis of muscle subcutaneous and muscle subcutaneous method |
| topic | Forearm autotransplantation Secondary hyperparathyroidism Muscle and subcutaneous transplantation |
| url | https://doi.org/10.1186/s12893-021-01222-2 |
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