Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases

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SM is a fundamental component of mammalian cell membranes that contributes to mechanical stability, signaling, and sorting. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS) 1 in the Golgi and SMS2 at the plasma m...

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Bibliographic Details
Main Authors: Matthijs Kol, Radhakrishnan Panatala, Mirjana Nordmann, Leoni Swart, Leonie van Suijlekom, Birol Cabukusta, Angelika Hilderink, Tanja Grabietz, John G.M. Mina, Pentti Somerharju, Sergei Korneev, Fikadu G. Tafesse, Joost C.M. Holthuis
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Lipid Research
Subjects:
cell-free expression
ceramide phosphoethanolamine
click chemistry
enzyme mechanisms
Golgi apparatus
lipid biochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351634

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