Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon
This study revealed different sensitivity of brain glioma cells (n=62) to the a-interferon (a-IFN) straight action in vitro depending on cytokine’s concentration. The glioma’s sensitivity to the cytotoxic a-IFN action was reduced according to the growth of the tumor malignancy level. 45%...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Romodanov Neurosurgery Institute
2005-12-01
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| Series: | Ukrainian Neurosurgical Journal |
| Online Access: | https://theunj.org/article/view/128595 |
| _version_ | 1797327927357997056 |
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| author | V. M. Semenova N. I. Lysyany L. D. Lyubych L. P. Stayno |
| author_facet | V. M. Semenova N. I. Lysyany L. D. Lyubych L. P. Stayno |
| author_sort | V. M. Semenova |
| collection | DOAJ |
| description |
This study revealed different sensitivity of brain glioma cells (n=62) to the a-interferon (a-IFN) straight action in vitro depending on cytokine’s concentration. The glioma’s sensitivity to the cytotoxic a-IFN action was reduced according to the growth of the tumor malignancy level. 45% of the benign astrocytomas, 30% of III anaplastic degree astrocytomas and 27,3% of IV anaplastic degree astrocytomas demonstrated the high sensitivity to a-IFN. Minimal tumor cells sensitivity to the a-IFN antitumor action was observed in 36,3% of glioblastomas, 25% of III anaplastic degree astrocytomas and 15% II anaplastic degree astrocytomas. |
| first_indexed | 2024-03-08T06:44:49Z |
| format | Article |
| id | doaj.art-f7515f33a52c4aa9993bf8dff8508eb9 |
| institution | Directory Open Access Journal |
| issn | 2663-9084 2663-9092 |
| language | English |
| last_indexed | 2024-03-08T06:44:49Z |
| publishDate | 2005-12-01 |
| publisher | Romodanov Neurosurgery Institute |
| record_format | Article |
| series | Ukrainian Neurosurgical Journal |
| spelling | doaj.art-f7515f33a52c4aa9993bf8dff8508eb92024-02-03T08:16:07ZengRomodanov Neurosurgery InstituteUkrainian Neurosurgical Journal2663-90842663-90922005-12-014263410.25305/unj.128595Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferonV. M. Semenova0N. I. Lysyany1L. D. Lyubych2L. P. Stayno3Romodanov Neurosurgery Institute, Kiev, UkraineRomodanov Neurosurgery Institute, Kiev, UkraineRomodanov Neurosurgery Institute, Kiev, UkraineRomodanov Neurosurgery Institute, Kiev, Ukraine This study revealed different sensitivity of brain glioma cells (n=62) to the a-interferon (a-IFN) straight action in vitro depending on cytokine’s concentration. The glioma’s sensitivity to the cytotoxic a-IFN action was reduced according to the growth of the tumor malignancy level. 45% of the benign astrocytomas, 30% of III anaplastic degree astrocytomas and 27,3% of IV anaplastic degree astrocytomas demonstrated the high sensitivity to a-IFN. Minimal tumor cells sensitivity to the a-IFN antitumor action was observed in 36,3% of glioblastomas, 25% of III anaplastic degree astrocytomas and 15% II anaplastic degree astrocytomas.https://theunj.org/article/view/128595 |
| spellingShingle | V. M. Semenova N. I. Lysyany L. D. Lyubych L. P. Stayno Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon Ukrainian Neurosurgical Journal |
| title | Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon |
| title_full | Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon |
| title_fullStr | Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon |
| title_full_unstemmed | Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon |
| title_short | Experimental-morphological evaluation of the brain glioma’s sensitivity to the a-interferon |
| title_sort | experimental morphological evaluation of the brain glioma s sensitivity to the a interferon |
| url | https://theunj.org/article/view/128595 |
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