Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series
Depression is a common mental health disorder that affects more than 260 million individuals worldwide. The aetiology of depression is likely multifactorial with biological, psychological and environmental factors. Subsequently, depression can present as a number of different subtypes with varying c...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Medicine in Microecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097820300264 |
| _version_ | 1818597065432760320 |
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| author | Rhys Collyer Annabel Clancy Thomas Borody |
| author_facet | Rhys Collyer Annabel Clancy Thomas Borody |
| author_sort | Rhys Collyer |
| collection | DOAJ |
| description | Depression is a common mental health disorder that affects more than 260 million individuals worldwide. The aetiology of depression is likely multifactorial with biological, psychological and environmental factors. Subsequently, depression can present as a number of different subtypes with varying chronicity and severity. Recently, the gut microbiome has been implicated in many gastrointestinal and extra-gastrointestinal conditions including depression. Neurological systemic effects on host biology via the gut microbiome can occur through the bidirectional link known as the gut-brain axis. Dysbiosis is the imbalance of gut flora which may instigate a dysregulated immune response and lead to disorders such as irritable bowel syndrome. In this case series, depression and irritable bowel syndrome may have a shared pathogenesis. Our study aimed to explore the effects of faecal microbiota transplantation, a procedure in which a healthy donor’s microbiota is transplanted into an unwell recipient, in three cases of concomitant depression and irritable bowel syndrome. A single centre, retrospective medical records review assessed demographics, diagnosis, medications, symptoms and medical history of the cases to determine the outcome of a faecal microbiota transplantation. Despite varying symptom onsets, types and levels of neurological and gastrointestinal symptoms there was an objective improvement in mood, medication and/or symptoms reported by the patient and/or attending physician. These results demonstrate a modest improvement in both depression and irritable bowel syndrome which would benefit from further investigation by randomised controlled trials. Faecal microbiota transplantation may be a potential adjunct therapy for treating depression and irritable bowel syndrome through the gut-brain axis. |
| first_indexed | 2024-12-16T11:41:53Z |
| format | Article |
| id | doaj.art-f753e5edbbca45069e8e730db770ad61 |
| institution | Directory Open Access Journal |
| issn | 2590-0978 |
| language | English |
| last_indexed | 2024-12-16T11:41:53Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj.art-f753e5edbbca45069e8e730db770ad612022-12-21T22:32:56ZengElsevierMedicine in Microecology2590-09782020-12-016100029Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case seriesRhys Collyer0Annabel Clancy1Thomas Borody2Centre for Digestive Diseases, Five Dock, NSW, AustraliaCentre for Digestive Diseases, Five Dock, NSW, AustraliaCorresponding author.; Centre for Digestive Diseases, Five Dock, NSW, AustraliaDepression is a common mental health disorder that affects more than 260 million individuals worldwide. The aetiology of depression is likely multifactorial with biological, psychological and environmental factors. Subsequently, depression can present as a number of different subtypes with varying chronicity and severity. Recently, the gut microbiome has been implicated in many gastrointestinal and extra-gastrointestinal conditions including depression. Neurological systemic effects on host biology via the gut microbiome can occur through the bidirectional link known as the gut-brain axis. Dysbiosis is the imbalance of gut flora which may instigate a dysregulated immune response and lead to disorders such as irritable bowel syndrome. In this case series, depression and irritable bowel syndrome may have a shared pathogenesis. Our study aimed to explore the effects of faecal microbiota transplantation, a procedure in which a healthy donor’s microbiota is transplanted into an unwell recipient, in three cases of concomitant depression and irritable bowel syndrome. A single centre, retrospective medical records review assessed demographics, diagnosis, medications, symptoms and medical history of the cases to determine the outcome of a faecal microbiota transplantation. Despite varying symptom onsets, types and levels of neurological and gastrointestinal symptoms there was an objective improvement in mood, medication and/or symptoms reported by the patient and/or attending physician. These results demonstrate a modest improvement in both depression and irritable bowel syndrome which would benefit from further investigation by randomised controlled trials. Faecal microbiota transplantation may be a potential adjunct therapy for treating depression and irritable bowel syndrome through the gut-brain axis.http://www.sciencedirect.com/science/article/pii/S2590097820300264DepressionFaecal microbiota transplantationMicrobiomeIrritable bowel syndromeGut-brain axis |
| spellingShingle | Rhys Collyer Annabel Clancy Thomas Borody Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series Medicine in Microecology Depression Faecal microbiota transplantation Microbiome Irritable bowel syndrome Gut-brain axis |
| title | Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series |
| title_full | Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series |
| title_fullStr | Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series |
| title_full_unstemmed | Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series |
| title_short | Faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome: A case series |
| title_sort | faecal microbiota transplantation alleviates symptoms of depression in individuals with irritable bowel syndrome a case series |
| topic | Depression Faecal microbiota transplantation Microbiome Irritable bowel syndrome Gut-brain axis |
| url | http://www.sciencedirect.com/science/article/pii/S2590097820300264 |
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