Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review
Despite being considered a public health emergency for the last 25 years, tuberculosis (TB) is still one of the deadliest infectious diseases, responsible for over a million deaths every year. The length and toxicity of available treatments and the increasing emergence of multidrug-resistant strains...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/4/323 |
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| author | Gabriel S. Oliveira Raquel P. Costa Paula Gomes Maria Salomé Gomes Tânia Silva Cátia Teixeira |
| author_facet | Gabriel S. Oliveira Raquel P. Costa Paula Gomes Maria Salomé Gomes Tânia Silva Cátia Teixeira |
| author_sort | Gabriel S. Oliveira |
| collection | DOAJ |
| description | Despite being considered a public health emergency for the last 25 years, tuberculosis (TB) is still one of the deadliest infectious diseases, responsible for over a million deaths every year. The length and toxicity of available treatments and the increasing emergence of multidrug-resistant strains of <i>Mycobacterium tuberculosis</i> renders standard regimens increasingly inefficient and emphasizes the urgency to develop new approaches that are not only cost- and time-effective but also less toxic. Antimicrobial peptides (AMP) are small cationic and amphipathic molecules that play a vital role in the host immune system by acting as a first barrier against invading pathogens. The broad spectrum of properties that peptides possess make them one of the best possible alternatives for a new “post-antibiotic” era. In this context, research into AMP as potential anti-tubercular agents has been driven by the increasing danger revolving around the emergence of extremely-resistant strains, the innate resistance that mycobacteria possess and the low compliance of patients towards the toxic anti-TB treatments. In this review, we will focus on AMP from various sources, such as animal, non-animal and synthetic, with reported inhibitory activity towards <i>Mycobacterium tuberculosis</i>. |
| first_indexed | 2024-03-10T12:40:09Z |
| format | Article |
| id | doaj.art-f7559c4b594e408db210edbfd5a0bbab |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T12:40:09Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f7559c4b594e408db210edbfd5a0bbab2023-11-21T13:57:32ZengMDPI AGPharmaceuticals1424-82472021-04-0114432310.3390/ph14040323Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise ReviewGabriel S. Oliveira0Raquel P. Costa1Paula Gomes2Maria Salomé Gomes3Tânia Silva4Cátia Teixeira5ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, P-4050-313 Porto, PortugalLAQV-REQUIMTE—Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, P-4050-313 Porto, PortugalLAQV-REQUIMTE—Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, P-4169-007 Porto, PortugalICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, P-4050-313 Porto, PortugalICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, P-4050-313 Porto, PortugalLAQV-REQUIMTE—Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, P-4169-007 Porto, PortugalDespite being considered a public health emergency for the last 25 years, tuberculosis (TB) is still one of the deadliest infectious diseases, responsible for over a million deaths every year. The length and toxicity of available treatments and the increasing emergence of multidrug-resistant strains of <i>Mycobacterium tuberculosis</i> renders standard regimens increasingly inefficient and emphasizes the urgency to develop new approaches that are not only cost- and time-effective but also less toxic. Antimicrobial peptides (AMP) are small cationic and amphipathic molecules that play a vital role in the host immune system by acting as a first barrier against invading pathogens. The broad spectrum of properties that peptides possess make them one of the best possible alternatives for a new “post-antibiotic” era. In this context, research into AMP as potential anti-tubercular agents has been driven by the increasing danger revolving around the emergence of extremely-resistant strains, the innate resistance that mycobacteria possess and the low compliance of patients towards the toxic anti-TB treatments. In this review, we will focus on AMP from various sources, such as animal, non-animal and synthetic, with reported inhibitory activity towards <i>Mycobacterium tuberculosis</i>.https://www.mdpi.com/1424-8247/14/4/323antimicrobial peptidesanti-tubercular drugsantibiotic resistancemycobacteriatuberculosis |
| spellingShingle | Gabriel S. Oliveira Raquel P. Costa Paula Gomes Maria Salomé Gomes Tânia Silva Cátia Teixeira Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review Pharmaceuticals antimicrobial peptides anti-tubercular drugs antibiotic resistance mycobacteria tuberculosis |
| title | Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review |
| title_full | Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review |
| title_fullStr | Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review |
| title_full_unstemmed | Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review |
| title_short | Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review |
| title_sort | antimicrobial peptides as potential anti tubercular leads a concise review |
| topic | antimicrobial peptides anti-tubercular drugs antibiotic resistance mycobacteria tuberculosis |
| url | https://www.mdpi.com/1424-8247/14/4/323 |
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