Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy
Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient’s brain is resected or functionally disconnected to manage seizures in individuals with drug-resistant epilepsy. Despite the extensive loss of both ventral and dorsal visual pathways in one hemisphere, pediatric patie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323001287 |
| _version_ | 1827591304030191616 |
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| author | Vladislav Ayzenberg Michael C. Granovetter Sophia Robert Christina Patterson Marlene Behrmann |
| author_facet | Vladislav Ayzenberg Michael C. Granovetter Sophia Robert Christina Patterson Marlene Behrmann |
| author_sort | Vladislav Ayzenberg |
| collection | DOAJ |
| description | Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient’s brain is resected or functionally disconnected to manage seizures in individuals with drug-resistant epilepsy. Despite the extensive loss of both ventral and dorsal visual pathways in one hemisphere, pediatric patients who have undergone hemispherectomy show a remarkably high degree of perceptual function across many domains. In the current study, we sought to understand the extent to which functions of the ventral and dorsal visual pathways reorganize to the contralateral hemisphere following childhood hemispherectomy. To this end, we collected fMRI data from an equal number of left and right hemispherectomy patients who completed tasks that typically elicit lateralized responses from the ventral or the dorsal pathway, namely, word (left ventral), face (right ventral), tool (left dorsal), and global form (right dorsal) perception. Overall, there was greater evidence of functional reorganization in the ventral pathway than in the dorsal pathway. Importantly, because ventral and dorsal reorganization was tested within the very same patients, these results cannot be explained by idiosyncratic factors such as disease etiology, age at the time of surgery, or age at testing. These findings suggest that because the dorsal pathway may mature earlier, it may have a shorter developmental window of plasticity than the ventral pathway and, hence, be less malleable after perturbation. |
| first_indexed | 2024-03-09T01:29:52Z |
| format | Article |
| id | doaj.art-f75610b1042f455fb7956052892f6905 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-09T01:29:52Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-f75610b1042f455fb7956052892f69052023-12-10T06:14:25ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-12-0164101323Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomyVladislav Ayzenberg0Michael C. Granovetter1Sophia Robert2Christina Patterson3Marlene Behrmann4Department of Psychology, University of Pennsylvania, PA, USA; Department of Psychology and Neuroscience Institute, Carnegie Mellon University, PA, USA; Corresponding author at: Department of Psychology, University of Pennsylvania, PA, USADepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, PA, USA; School of Medicine, University of Pittsburgh, PA, USADepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, PA, USASchool of Medicine, University of Pittsburgh, PA, USA; Department of Pediatrics, University of Pittsburgh, PA, USADepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, PA, USA; Department of Pediatrics, University of Pittsburgh, PA, USA; Department of Ophthalmology, University of Pittsburgh, PA, USA; Corresponding author at: Department of Psychology and Neuroscience Institute, Carnegie Mellon University, PA, USA.Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient’s brain is resected or functionally disconnected to manage seizures in individuals with drug-resistant epilepsy. Despite the extensive loss of both ventral and dorsal visual pathways in one hemisphere, pediatric patients who have undergone hemispherectomy show a remarkably high degree of perceptual function across many domains. In the current study, we sought to understand the extent to which functions of the ventral and dorsal visual pathways reorganize to the contralateral hemisphere following childhood hemispherectomy. To this end, we collected fMRI data from an equal number of left and right hemispherectomy patients who completed tasks that typically elicit lateralized responses from the ventral or the dorsal pathway, namely, word (left ventral), face (right ventral), tool (left dorsal), and global form (right dorsal) perception. Overall, there was greater evidence of functional reorganization in the ventral pathway than in the dorsal pathway. Importantly, because ventral and dorsal reorganization was tested within the very same patients, these results cannot be explained by idiosyncratic factors such as disease etiology, age at the time of surgery, or age at testing. These findings suggest that because the dorsal pathway may mature earlier, it may have a shorter developmental window of plasticity than the ventral pathway and, hence, be less malleable after perturbation.http://www.sciencedirect.com/science/article/pii/S1878929323001287PlasticityVentral streamDorsal streamHemispherectomyNeuropsychologyBrain development |
| spellingShingle | Vladislav Ayzenberg Michael C. Granovetter Sophia Robert Christina Patterson Marlene Behrmann Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy Developmental Cognitive Neuroscience Plasticity Ventral stream Dorsal stream Hemispherectomy Neuropsychology Brain development |
| title | Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy |
| title_full | Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy |
| title_fullStr | Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy |
| title_full_unstemmed | Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy |
| title_short | Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy |
| title_sort | differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy |
| topic | Plasticity Ventral stream Dorsal stream Hemispherectomy Neuropsychology Brain development |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323001287 |
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