Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea
Abstract The relationship between sleep apnea and morning affectivity remains unclear. We aimed to clarify how sleep disturbance in patients with obstructive sleep apnea (OSA) influences their affectivity. The enrolled participants underwent the Positive and Negative Affect Schedule on their beds im...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25842-7 |
| _version_ | 1811179160521932800 |
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| author | Hajime Kumagai Hiroyuki Sawatari Yuka Kiyohara Akiko Kanoh Kana Asada Kengo Kawaguchi Aki Arita Yoko Murase Noriyuki Konishi Tetsuro Hoshino Mitsuo Hayashi Toshiaki Shiomi |
| author_facet | Hajime Kumagai Hiroyuki Sawatari Yuka Kiyohara Akiko Kanoh Kana Asada Kengo Kawaguchi Aki Arita Yoko Murase Noriyuki Konishi Tetsuro Hoshino Mitsuo Hayashi Toshiaki Shiomi |
| author_sort | Hajime Kumagai |
| collection | DOAJ |
| description | Abstract The relationship between sleep apnea and morning affectivity remains unclear. We aimed to clarify how sleep disturbance in patients with obstructive sleep apnea (OSA) influences their affectivity. The enrolled participants underwent the Positive and Negative Affect Schedule on their beds immediately before and after overnight polysomnography. Thirty patients with OSA were divided into two groups according to the apnea–hypopnea index (AHI): mild to moderate OSA (5 ≤ AHI < 30/h) and severe OSA (AHI ≥ 30/h) groups. Additionally, 11 healthy participants (AHI < 5/h) were included as the control group. No independent association was found between affectivity and OSA severity markers in the whole population; however, the severe OSA group had a significantly higher cumulative percentage of sleep time at saturations < 90% (CT90) and worsened morning negative affectivity. Multiple regression analysis showed that CT90 was an independent factor for increasing negative affectivity in the severe OSA group (p = 0.0422). In patients with OSA, the receiver operating characteristic curve analysis showed that the best cutoff value for CT90 for predicting no decrease in negative affectivity after sleep was 1.0% (sensitivity = 0.56, specificity = 0.86); the corresponding area under the curve was 0.71. Worsening of negative affectivity in the morning was influenced by nocturnal hypoxemia in patients with severe OSA. |
| first_indexed | 2024-04-11T06:30:05Z |
| format | Article |
| id | doaj.art-f7564922b5cd49179bf2cd06445d7083 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T06:30:05Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f7564922b5cd49179bf2cd06445d70832022-12-22T04:40:08ZengNature PortfolioScientific Reports2045-23222022-12-011211910.1038/s41598-022-25842-7Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apneaHajime Kumagai0Hiroyuki Sawatari1Yuka Kiyohara2Akiko Kanoh3Kana Asada4Kengo Kawaguchi5Aki Arita6Yoko Murase7Noriyuki Konishi8Tetsuro Hoshino9Mitsuo Hayashi10Toshiaki Shiomi11Department of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDivision of Clinical Support, Hiroshima University HospitalDivision of Clinical Support, Hiroshima University HospitalDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityGraduate School of Humanities and Social Sciences, Hiroshima UniversityDepartment of Sleep Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima UniversityAbstract The relationship between sleep apnea and morning affectivity remains unclear. We aimed to clarify how sleep disturbance in patients with obstructive sleep apnea (OSA) influences their affectivity. The enrolled participants underwent the Positive and Negative Affect Schedule on their beds immediately before and after overnight polysomnography. Thirty patients with OSA were divided into two groups according to the apnea–hypopnea index (AHI): mild to moderate OSA (5 ≤ AHI < 30/h) and severe OSA (AHI ≥ 30/h) groups. Additionally, 11 healthy participants (AHI < 5/h) were included as the control group. No independent association was found between affectivity and OSA severity markers in the whole population; however, the severe OSA group had a significantly higher cumulative percentage of sleep time at saturations < 90% (CT90) and worsened morning negative affectivity. Multiple regression analysis showed that CT90 was an independent factor for increasing negative affectivity in the severe OSA group (p = 0.0422). In patients with OSA, the receiver operating characteristic curve analysis showed that the best cutoff value for CT90 for predicting no decrease in negative affectivity after sleep was 1.0% (sensitivity = 0.56, specificity = 0.86); the corresponding area under the curve was 0.71. Worsening of negative affectivity in the morning was influenced by nocturnal hypoxemia in patients with severe OSA.https://doi.org/10.1038/s41598-022-25842-7 |
| spellingShingle | Hajime Kumagai Hiroyuki Sawatari Yuka Kiyohara Akiko Kanoh Kana Asada Kengo Kawaguchi Aki Arita Yoko Murase Noriyuki Konishi Tetsuro Hoshino Mitsuo Hayashi Toshiaki Shiomi Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea Scientific Reports |
| title | Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea |
| title_full | Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea |
| title_fullStr | Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea |
| title_full_unstemmed | Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea |
| title_short | Nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea |
| title_sort | nocturnal hypoxemia is related to morning negative affectivity in untreated patients with severe obstructive sleep apnea |
| url | https://doi.org/10.1038/s41598-022-25842-7 |
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