Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity
Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-06-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861316300366 |
| _version_ | 1811314112298221568 |
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| author | Kuniaki Tsutsumi Takanori Kaname Haruka Shiraishi Takehiro Kawashiri Nobuaki Egashira |
| author_facet | Kuniaki Tsutsumi Takanori Kaname Haruka Shiraishi Takehiro Kawashiri Nobuaki Egashira |
| author_sort | Kuniaki Tsutsumi |
| collection | DOAJ |
| description | Paclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg/kg, i.p., on days 1, 3, 5 and 7) and suppressed the paclitaxel-induced increase in macrophage migration in dorsal root ganglion cells. In addition, polaprezinc did not affect the anti-tumor activity of paclitaxel in cultured cell lines or tumor-bearing mice. These results suggest a clinical indication for polaprezinc in the prevention of paclitaxel-induced neuropathy. |
| first_indexed | 2024-04-13T11:06:09Z |
| format | Article |
| id | doaj.art-f7573b8aee2a406482c7393c09affe3b |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T11:06:09Z |
| publishDate | 2016-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-f7573b8aee2a406482c7393c09affe3b2022-12-22T02:49:16ZengElsevierJournal of Pharmacological Sciences1347-86132016-06-01131214614910.1016/j.jphs.2016.04.019Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activityKuniaki TsutsumiTakanori KanameHaruka ShiraishiTakehiro KawashiriNobuaki EgashiraPaclitaxel, an anticancer drug, frequently causes painful peripheral neuropathy. In this study, we investigated the preventive effect of polaprezinc on paclitaxel-induced peripheral neuropathy in rats. Polaprezinc (3 mg/kg, p.o., once daily) inhibited the development of mechanical allodynia induced by paclitaxel (4 mg/kg, i.p., on days 1, 3, 5 and 7) and suppressed the paclitaxel-induced increase in macrophage migration in dorsal root ganglion cells. In addition, polaprezinc did not affect the anti-tumor activity of paclitaxel in cultured cell lines or tumor-bearing mice. These results suggest a clinical indication for polaprezinc in the prevention of paclitaxel-induced neuropathy.http://www.sciencedirect.com/science/article/pii/S1347861316300366PaclitaxelPeripheral neuropathyPolaprezinc |
| spellingShingle | Kuniaki Tsutsumi Takanori Kaname Haruka Shiraishi Takehiro Kawashiri Nobuaki Egashira Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity Journal of Pharmacological Sciences Paclitaxel Peripheral neuropathy Polaprezinc |
| title | Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity |
| title_full | Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity |
| title_fullStr | Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity |
| title_full_unstemmed | Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity |
| title_short | Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity |
| title_sort | polaprezinc reduces paclitaxel induced peripheral neuropathy in rats without affecting anti tumor activity |
| topic | Paclitaxel Peripheral neuropathy Polaprezinc |
| url | http://www.sciencedirect.com/science/article/pii/S1347861316300366 |
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