Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study
Background: Bisphenol A [BPA] is widely used in industrial processes. It persists in environment and exerts a harmful action on human health, through endocrine-disruption. Many natural compounds are suggested to have a preventive effect on BPA-induced human health hazards.Aim of the work: This study...
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| Format: | Article |
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Al-Azhar University, Faculty of Medicine (Damietta)
2022-02-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_221970_2ec114e7f8d8155059a2d3dee661deac.pdf |
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| author | Ibrahim Mahrous Ibrahim Amr Osama Mohammed Abd El Hay Mohamed Gaber Mohamed Hasan Mahmoud Diab Amal H. Ibrahim Ahmed Mohammed Taha Samir Atef Farid Elmetwally Moaaz Moustafa Yousef Awad |
| author_facet | Ibrahim Mahrous Ibrahim Amr Osama Mohammed Abd El Hay Mohamed Gaber Mohamed Hasan Mahmoud Diab Amal H. Ibrahim Ahmed Mohammed Taha Samir Atef Farid Elmetwally Moaaz Moustafa Yousef Awad |
| author_sort | Ibrahim Mahrous Ibrahim Amr |
| collection | DOAJ |
| description | Background: Bisphenol A [BPA] is widely used in industrial processes. It persists in environment and exerts a harmful action on human health, through endocrine-disruption. Many natural compounds are suggested to have a preventive effect on BPA-induced human health hazards.Aim of the work: This study aimed to evaluate the effect of Silymarin/Curcumin in ameliorating the hepatotoxic effect induced in albino rats following oral administration of BPA.Patients and Methods: Fourty adult male albino rats were included and randomly categorized into four equal groups. The control group and BPA-exposed [50 mg/kg] group. Groups 3 and 4 for rats received oral BPA [50 mg/kg] plus [100 mg/ kg] of curcumin or silymarin. Serum liver enzymes, pro-inflammatory cytokines [TNF-α & IL-1,6,8] and the oxidant/antioxidant profile were assessed in the serum. SOD, GPX and CAT levels, MDA and H2O2 were assessed. Histopathological changes of the liver, immunohistochemical detection of caspase 3 and area density of collagen fibres were also assessed.Results: Bisphenol-A administration for 30 days was associated with a significant increase in the number of pro-inflammatory markers as interleukin 1,6,8 and tumor necrosis factor‑α [TNF-α]. It also, stimulates oxidative stress with structural changes, apoptosis and fibrosis in hepatic cells. Treatment with curcumin or silymarin for 30 days lead to a reduction of pro‑inflammatory mediators and significant amelioration of structural changes.Conclusion: Silymarin/Curcumin had an ameliorative of harmful effects of BPA on the liver cells through potent anti-inflammatory, antiapoptotic and antioxidant effects. |
| first_indexed | 2024-04-14T00:19:34Z |
| format | Article |
| id | doaj.art-f757480bcba64331b271e889e853fe22 |
| institution | Directory Open Access Journal |
| issn | 2636-4174 2682-3780 |
| language | English |
| last_indexed | 2024-04-14T00:19:34Z |
| publishDate | 2022-02-01 |
| publisher | Al-Azhar University, Faculty of Medicine (Damietta) |
| record_format | Article |
| series | International Journal of Medical Arts |
| spelling | doaj.art-f757480bcba64331b271e889e853fe222022-12-22T02:23:00ZengAl-Azhar University, Faculty of Medicine (Damietta)International Journal of Medical Arts2636-41742682-37802022-02-01422141214810.21608/ijma.2022.221970221970Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental StudyIbrahim Mahrous Ibrahim Amr0Osama Mohammed Abd El Hay1Mohamed Gaber Mohamed Hasan2Mahmoud Diab3Amal H. Ibrahim4Ahmed Mohammed Taha5Samir Atef Farid Elmetwally6Moaaz Moustafa Yousef Awad7Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of Physiology, Faculty of Medicine, Al-Azhar University, EgyptDepartment of Physiology, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, EgyptDepartment of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, EgyptDepartment of Pharmacology, Faculty of Medicine, Helwan University, EgyptDepartment of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, EgyptDepartment of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, EgyptBackground: Bisphenol A [BPA] is widely used in industrial processes. It persists in environment and exerts a harmful action on human health, through endocrine-disruption. Many natural compounds are suggested to have a preventive effect on BPA-induced human health hazards.Aim of the work: This study aimed to evaluate the effect of Silymarin/Curcumin in ameliorating the hepatotoxic effect induced in albino rats following oral administration of BPA.Patients and Methods: Fourty adult male albino rats were included and randomly categorized into four equal groups. The control group and BPA-exposed [50 mg/kg] group. Groups 3 and 4 for rats received oral BPA [50 mg/kg] plus [100 mg/ kg] of curcumin or silymarin. Serum liver enzymes, pro-inflammatory cytokines [TNF-α & IL-1,6,8] and the oxidant/antioxidant profile were assessed in the serum. SOD, GPX and CAT levels, MDA and H2O2 were assessed. Histopathological changes of the liver, immunohistochemical detection of caspase 3 and area density of collagen fibres were also assessed.Results: Bisphenol-A administration for 30 days was associated with a significant increase in the number of pro-inflammatory markers as interleukin 1,6,8 and tumor necrosis factor‑α [TNF-α]. It also, stimulates oxidative stress with structural changes, apoptosis and fibrosis in hepatic cells. Treatment with curcumin or silymarin for 30 days lead to a reduction of pro‑inflammatory mediators and significant amelioration of structural changes.Conclusion: Silymarin/Curcumin had an ameliorative of harmful effects of BPA on the liver cells through potent anti-inflammatory, antiapoptotic and antioxidant effects.https://ijma.journals.ekb.eg/article_221970_2ec114e7f8d8155059a2d3dee661deac.pdfbisphenol aliver, oxidative stresshepatoprotectivesilymarincurcumin |
| spellingShingle | Ibrahim Mahrous Ibrahim Amr Osama Mohammed Abd El Hay Mohamed Gaber Mohamed Hasan Mahmoud Diab Amal H. Ibrahim Ahmed Mohammed Taha Samir Atef Farid Elmetwally Moaaz Moustafa Yousef Awad Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study International Journal of Medical Arts bisphenol a liver, oxidative stress hepatoprotective silymarin curcumin |
| title | Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study |
| title_full | Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study |
| title_fullStr | Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study |
| title_full_unstemmed | Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study |
| title_short | Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study |
| title_sort | curcumin and silymarin amelioration of the bisphenol a induced hepatotoxic effects in male albino rats a structural biochemical and molecular experimental study |
| topic | bisphenol a liver, oxidative stress hepatoprotective silymarin curcumin |
| url | https://ijma.journals.ekb.eg/article_221970_2ec114e7f8d8155059a2d3dee661deac.pdf |
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