The mechanisms behind perivascular fluid flow.
Flow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscil...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0244442 |
| _version_ | 1819025594315177984 |
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| author | Cécile Daversin-Catty Vegard Vinje Kent-André Mardal Marie E Rognes |
| author_facet | Cécile Daversin-Catty Vegard Vinje Kent-André Mardal Marie E Rognes |
| author_sort | Cécile Daversin-Catty |
| collection | DOAJ |
| description | Flow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscillatory particle movement has a clear cardiac component, while the mechanisms involved in net movement remain disputed. Using computational fluid dynamics, we computed the CSF velocity and pressure in a PVS surrounding a cerebral artery subject to different forces, representing arterial wall expansion, systemic CSF pressure changes and rigid motions of the artery. The arterial wall expansion generated velocity amplitudes of 60-260 μm/s, which is in the upper range of previously observed values. In the absence of a static pressure gradient, predicted net flow velocities were small (<0.5 μm/s), though reaching up to 7 μm/s for non-physiological PVS lengths. In realistic geometries, a static systemic pressure increase of physiologically plausible magnitude was sufficient to induce net flow velocities of 20-30 μm/s. Moreover, rigid motions of the artery added to the complexity of flow patterns in the PVS. Our study demonstrates that the combination of arterial wall expansion, rigid motions and a static CSF pressure gradient generates net and oscillatory PVS flow, quantitatively comparable with experimental findings. The static CSF pressure gradient required for net flow is small, suggesting that its origin is yet to be determined. |
| first_indexed | 2024-12-21T05:13:10Z |
| format | Article |
| id | doaj.art-f758f13b37664257aff06a2f88db48c8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T05:13:10Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f758f13b37664257aff06a2f88db48c82022-12-21T19:14:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-011512e024444210.1371/journal.pone.0244442The mechanisms behind perivascular fluid flow.Cécile Daversin-CattyVegard VinjeKent-André MardalMarie E RognesFlow of cerebrospinal fluid (CSF) in perivascular spaces (PVS) is one of the key concepts involved in theories concerning clearance from the brain. Experimental studies have demonstrated both net and oscillatory movement of microspheres in PVS (Mestre et al. (2018), Bedussi et al. (2018)). The oscillatory particle movement has a clear cardiac component, while the mechanisms involved in net movement remain disputed. Using computational fluid dynamics, we computed the CSF velocity and pressure in a PVS surrounding a cerebral artery subject to different forces, representing arterial wall expansion, systemic CSF pressure changes and rigid motions of the artery. The arterial wall expansion generated velocity amplitudes of 60-260 μm/s, which is in the upper range of previously observed values. In the absence of a static pressure gradient, predicted net flow velocities were small (<0.5 μm/s), though reaching up to 7 μm/s for non-physiological PVS lengths. In realistic geometries, a static systemic pressure increase of physiologically plausible magnitude was sufficient to induce net flow velocities of 20-30 μm/s. Moreover, rigid motions of the artery added to the complexity of flow patterns in the PVS. Our study demonstrates that the combination of arterial wall expansion, rigid motions and a static CSF pressure gradient generates net and oscillatory PVS flow, quantitatively comparable with experimental findings. The static CSF pressure gradient required for net flow is small, suggesting that its origin is yet to be determined.https://doi.org/10.1371/journal.pone.0244442 |
| spellingShingle | Cécile Daversin-Catty Vegard Vinje Kent-André Mardal Marie E Rognes The mechanisms behind perivascular fluid flow. PLoS ONE |
| title | The mechanisms behind perivascular fluid flow. |
| title_full | The mechanisms behind perivascular fluid flow. |
| title_fullStr | The mechanisms behind perivascular fluid flow. |
| title_full_unstemmed | The mechanisms behind perivascular fluid flow. |
| title_short | The mechanisms behind perivascular fluid flow. |
| title_sort | mechanisms behind perivascular fluid flow |
| url | https://doi.org/10.1371/journal.pone.0244442 |
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