The Trial within Cohorts (TwiCs) study design in oncology: experience and methodological reflections

The Trial within Cohorts (TwiCs) study design in oncology: experience and methodological reflections

Abstract A Trial within Cohorts (TwiCs) study design is a trial design that uses the infrastructure of an observational cohort study to initiate a randomized trial. Upon cohort enrollment, the participants provide consent for being randomized in future studies without being informed. Once a new trea...

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Bibliographic Details
Main Authors: Rob Kessels, Anne M. May, Miriam Koopman, Kit C. B. Roes
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Medical Research Methodology
Subjects:
Trials within Cohorts
TwiCs
Cohort multiple randomized controlled trial
Oncology
Non-compliance
Efficacy estimand
Online Access:https://doi.org/10.1186/s12874-023-01941-5

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