Multiporphyrinic architectures: Advances in structural design for photodynamic therapy
Abstract Rationally designed multiporphyrinic architectures for boosting photodynamic therapy (PDT) have attracted significant attentions recently years due to their great potential for light‐mediated generation of reactive oxygen species. However, there is still a gap between the structure design a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Aggregate |
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| Online Access: | https://doi.org/10.1002/agt2.420 |
| _version_ | 1827347376470228992 |
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| author | Yuwei Gao Yan Li Zhengwei Xu Shuangjiang Yu Junqiu Liu Hongcheng Sun |
| author_facet | Yuwei Gao Yan Li Zhengwei Xu Shuangjiang Yu Junqiu Liu Hongcheng Sun |
| author_sort | Yuwei Gao |
| collection | DOAJ |
| description | Abstract Rationally designed multiporphyrinic architectures for boosting photodynamic therapy (PDT) have attracted significant attentions recently years due to their great potential for light‐mediated generation of reactive oxygen species. However, there is still a gap between the structure design and their PDT performance for biomedical applications. This tutorial review provides a historical overview on (i) the basic concept of PDT for deeply understanding the porphyrin‐mediated PDT reactions, (ii) developing strategies for constructing porphyrinic architectures, like nanorings, boxes, metal‐organic frameworks (MOFs), covalent‐organic frameworks (COFs), vesicles, etc., where we classified into the following three categories: multiporphyrin arrays, porphyrinic frameworks, and others porphyrin assemblies, (iii) the various application scenarios for clinical cancer therapy and antibacterial infection. Also, the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section. Moreover, the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs, design of personalized “all‐in‐one” theranostic agents, and the popularization and application in wider biomedical fields. |
| first_indexed | 2024-03-07T23:47:43Z |
| format | Article |
| id | doaj.art-f759c2bba93c4206a2aa51c14dd1a0c6 |
| institution | Directory Open Access Journal |
| issn | 2692-4560 |
| language | English |
| last_indexed | 2024-03-07T23:47:43Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj.art-f759c2bba93c4206a2aa51c14dd1a0c62024-02-19T11:04:09ZengWileyAggregate2692-45602024-02-0151n/an/a10.1002/agt2.420Multiporphyrinic architectures: Advances in structural design for photodynamic therapyYuwei Gao0Yan Li1Zhengwei Xu2Shuangjiang Yu3Junqiu Liu4Hongcheng Sun5College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou ChinaCollege of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou ChinaCollege of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou ChinaCollege of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou ChinaCollege of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou ChinaCollege of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou ChinaAbstract Rationally designed multiporphyrinic architectures for boosting photodynamic therapy (PDT) have attracted significant attentions recently years due to their great potential for light‐mediated generation of reactive oxygen species. However, there is still a gap between the structure design and their PDT performance for biomedical applications. This tutorial review provides a historical overview on (i) the basic concept of PDT for deeply understanding the porphyrin‐mediated PDT reactions, (ii) developing strategies for constructing porphyrinic architectures, like nanorings, boxes, metal‐organic frameworks (MOFs), covalent‐organic frameworks (COFs), vesicles, etc., where we classified into the following three categories: multiporphyrin arrays, porphyrinic frameworks, and others porphyrin assemblies, (iii) the various application scenarios for clinical cancer therapy and antibacterial infection. Also, the existing challenges and future perspectives on the innovation of porphyrinic architectures for clinical PDT applications are mentioned in the end section. Moreover, the porphyrinic nanomaterials with atomically precise architectures provide an ideal platform for investigating the relationship between structures and PDT outputs, design of personalized “all‐in‐one” theranostic agents, and the popularization and application in wider biomedical fields.https://doi.org/10.1002/agt2.420covalent‐organic frameworks (COFs)metal‐organic frameworks (MOFs)multiporphyrin arraysphotodynamic therapy (PDT)porphyrinic architectures |
| spellingShingle | Yuwei Gao Yan Li Zhengwei Xu Shuangjiang Yu Junqiu Liu Hongcheng Sun Multiporphyrinic architectures: Advances in structural design for photodynamic therapy Aggregate covalent‐organic frameworks (COFs) metal‐organic frameworks (MOFs) multiporphyrin arrays photodynamic therapy (PDT) porphyrinic architectures |
| title | Multiporphyrinic architectures: Advances in structural design for photodynamic therapy |
| title_full | Multiporphyrinic architectures: Advances in structural design for photodynamic therapy |
| title_fullStr | Multiporphyrinic architectures: Advances in structural design for photodynamic therapy |
| title_full_unstemmed | Multiporphyrinic architectures: Advances in structural design for photodynamic therapy |
| title_short | Multiporphyrinic architectures: Advances in structural design for photodynamic therapy |
| title_sort | multiporphyrinic architectures advances in structural design for photodynamic therapy |
| topic | covalent‐organic frameworks (COFs) metal‐organic frameworks (MOFs) multiporphyrin arrays photodynamic therapy (PDT) porphyrinic architectures |
| url | https://doi.org/10.1002/agt2.420 |
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