Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors
The tumour microenvironment (TME) plays a crucial role in the regulation of cell survival and growth by providing inhibitory or stimulatory signals. Extracellular vesicles (EV) represent one of the most relevant cell-to-cell communication mechanism among cells within the TME. Moreover, EV contribute...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6768 |
| _version_ | 1797553686488023040 |
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| author | Claudia Cavallari Giovanni Camussi Maria Felice Brizzi |
| author_facet | Claudia Cavallari Giovanni Camussi Maria Felice Brizzi |
| author_sort | Claudia Cavallari |
| collection | DOAJ |
| description | The tumour microenvironment (TME) plays a crucial role in the regulation of cell survival and growth by providing inhibitory or stimulatory signals. Extracellular vesicles (EV) represent one of the most relevant cell-to-cell communication mechanism among cells within the TME. Moreover, EV contribute to the crosstalk among cancerous, immune, endothelial, and stromal cells to establish TME diversity. EV contain proteins, mRNAs and miRNAs, which can be locally delivered in the TME and/or transferred to remote sites to dictate tumour behaviour. EV in the TME impact on cancer cell proliferation, invasion, metastasis, immune-escape, pre-metastatic niche formation and the stimulation of angiogenesis. Moreover, EV can boost or inhibit tumours depending on the TME conditions and their cell of origin. Therefore, to move towards the identification of new targets and the development of a novel generation of EV-based targeting approaches to gain insight into EV mechanism of action in the TME would be of particular relevance. The aim here is to provide an overview of the current knowledge of EV released from different TME cellular components and their role in driving TME diversity. Moreover, recent proposed engineering approaches to targeting cells in the TME via EV are discussed. |
| first_indexed | 2024-03-10T16:19:08Z |
| format | Article |
| id | doaj.art-f759c8becd2e4c9797f1be41e20abcf6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:19:08Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f759c8becd2e4c9797f1be41e20abcf62023-11-20T13:49:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118676810.3390/ijms21186768Extracellular Vesicles in the Tumour Microenvironment: Eclectic SupervisorsClaudia Cavallari0Giovanni Camussi1Maria Felice Brizzi22i3T Scarl, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, University of Turin, 10126 Turin, ItalyDepartment of Medical Sciences, University of Turin, 10126 Turin, ItalyThe tumour microenvironment (TME) plays a crucial role in the regulation of cell survival and growth by providing inhibitory or stimulatory signals. Extracellular vesicles (EV) represent one of the most relevant cell-to-cell communication mechanism among cells within the TME. Moreover, EV contribute to the crosstalk among cancerous, immune, endothelial, and stromal cells to establish TME diversity. EV contain proteins, mRNAs and miRNAs, which can be locally delivered in the TME and/or transferred to remote sites to dictate tumour behaviour. EV in the TME impact on cancer cell proliferation, invasion, metastasis, immune-escape, pre-metastatic niche formation and the stimulation of angiogenesis. Moreover, EV can boost or inhibit tumours depending on the TME conditions and their cell of origin. Therefore, to move towards the identification of new targets and the development of a novel generation of EV-based targeting approaches to gain insight into EV mechanism of action in the TME would be of particular relevance. The aim here is to provide an overview of the current knowledge of EV released from different TME cellular components and their role in driving TME diversity. Moreover, recent proposed engineering approaches to targeting cells in the TME via EV are discussed.https://www.mdpi.com/1422-0067/21/18/6768extracellular vesiclestumour microenvironmentEV engineering |
| spellingShingle | Claudia Cavallari Giovanni Camussi Maria Felice Brizzi Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors International Journal of Molecular Sciences extracellular vesicles tumour microenvironment EV engineering |
| title | Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors |
| title_full | Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors |
| title_fullStr | Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors |
| title_full_unstemmed | Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors |
| title_short | Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors |
| title_sort | extracellular vesicles in the tumour microenvironment eclectic supervisors |
| topic | extracellular vesicles tumour microenvironment EV engineering |
| url | https://www.mdpi.com/1422-0067/21/18/6768 |
| work_keys_str_mv | AT claudiacavallari extracellularvesiclesinthetumourmicroenvironmenteclecticsupervisors AT giovannicamussi extracellularvesiclesinthetumourmicroenvironmenteclecticsupervisors AT mariafelicebrizzi extracellularvesiclesinthetumourmicroenvironmenteclecticsupervisors |