Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction
PurposeCardiac magnetic resonance imaging (cMRI) represents the gold standard to detect myocarditis. Left ventricular (LV) deformation imaging provides additional diagnostic options presumably exceeding conventional transthoracic echocardiography (TTE). The present study aimed to analyze the feasibi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1322145/full |
| _version_ | 1827386828166004736 |
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| author | Joscha Kandels Sarah Richter Andreas Hagendorff Kristian Kragholm Kristian Kragholm Bhupendar Tayal Ulrich Laufs Timm Denecke Stephan Stöbe |
| author_facet | Joscha Kandels Sarah Richter Andreas Hagendorff Kristian Kragholm Kristian Kragholm Bhupendar Tayal Ulrich Laufs Timm Denecke Stephan Stöbe |
| author_sort | Joscha Kandels |
| collection | DOAJ |
| description | PurposeCardiac magnetic resonance imaging (cMRI) represents the gold standard to detect myocarditis. Left ventricular (LV) deformation imaging provides additional diagnostic options presumably exceeding conventional transthoracic echocardiography (TTE). The present study aimed to analyze the feasibility to detect myocarditis in patients (pts) with preserved LV ejection fraction (LVEF) by TTE compared to cMRI. It has been hypothesized that the number of pathological findings by deformation imaging correspond to findings in cMRI.Methods and resultsBetween January 2018 and February 2020 102 pts with acute myocarditis according to the modified Lake Louise criteria and early gadolinium enhancement (EGE) by cMRI were identified at the department of cardiology at the University Hospital Leipzig. Twenty-six pts were included in this retrospective comparative study based on specific selection criteria. Twelve pts with normal cMRI served as a control group. LV deformation was analyzed by global and regional longitudinal strain (GLS, rLS), global and regional circumferential and radial strain (GCS, rCS, GRS, rRS), and LV rotation (including layer strain analysis). All parameters were compared to findings of edema, inflammation, and fibrosis by cMRI according to Lake Louise criteria. All pts with acute myocarditis diagnosed by cMRI showed pathological findings in TTE. Especially rCS and LV rotation analyzed by regional layer strain exhibit a high concordance with pathological findings in cMRI. In controls no LV deformation abnormalities were documented. Mean values of GLS, GRS, and GCS were not significantly different between pts with acute myocarditis and controls.ConclusionThis retrospective analysis documents the feasibility of detecting regional deformation abnormalities by echocardiography in patients with acute myocarditis confirmed by cMRI. The detection of pathological findings due to myocarditis requires the determination of regional deformation parameters, particularly rCS and LV rotation. The assessment of global strain values does not appear to be of critical value. |
| first_indexed | 2024-03-08T15:52:14Z |
| format | Article |
| id | doaj.art-f75a6005325148bca2f4bd796e0e4908 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T15:52:14Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-f75a6005325148bca2f4bd796e0e49082024-01-09T04:46:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-01-011010.3389/fcvm.2023.13221451322145Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fractionJoscha Kandels0Sarah Richter1Andreas Hagendorff2Kristian Kragholm3Kristian Kragholm4Bhupendar Tayal5Ulrich Laufs6Timm Denecke7Stephan Stöbe8Department of Cardiology, Leipzig University Hospital, Leipzig, GermanyDepartment of Internal Medicine I, Martha-Maria Hospital Halle-Dölau, Halle (Saale), GermanyDepartment of Cardiology, Leipzig University Hospital, Leipzig, GermanyDepartment of Cardiology, Aalborg University Hospital, Aalborg, DenmarkUnit of Clinical Biostatistics and Epidemiology, Aalborg University Hospital, Aalborg, DenmarkHouston Methodist DeBakey Heart and Vascular Center, Houston, TX, United StatesDepartment of Cardiology, Leipzig University Hospital, Leipzig, GermanyDepartment of Diagnostic and Interventional Radiology, University Hospital Leipzig, Leipzig, GermanyDepartment of Cardiology, Leipzig University Hospital, Leipzig, GermanyPurposeCardiac magnetic resonance imaging (cMRI) represents the gold standard to detect myocarditis. Left ventricular (LV) deformation imaging provides additional diagnostic options presumably exceeding conventional transthoracic echocardiography (TTE). The present study aimed to analyze the feasibility to detect myocarditis in patients (pts) with preserved LV ejection fraction (LVEF) by TTE compared to cMRI. It has been hypothesized that the number of pathological findings by deformation imaging correspond to findings in cMRI.Methods and resultsBetween January 2018 and February 2020 102 pts with acute myocarditis according to the modified Lake Louise criteria and early gadolinium enhancement (EGE) by cMRI were identified at the department of cardiology at the University Hospital Leipzig. Twenty-six pts were included in this retrospective comparative study based on specific selection criteria. Twelve pts with normal cMRI served as a control group. LV deformation was analyzed by global and regional longitudinal strain (GLS, rLS), global and regional circumferential and radial strain (GCS, rCS, GRS, rRS), and LV rotation (including layer strain analysis). All parameters were compared to findings of edema, inflammation, and fibrosis by cMRI according to Lake Louise criteria. All pts with acute myocarditis diagnosed by cMRI showed pathological findings in TTE. Especially rCS and LV rotation analyzed by regional layer strain exhibit a high concordance with pathological findings in cMRI. In controls no LV deformation abnormalities were documented. Mean values of GLS, GRS, and GCS were not significantly different between pts with acute myocarditis and controls.ConclusionThis retrospective analysis documents the feasibility of detecting regional deformation abnormalities by echocardiography in patients with acute myocarditis confirmed by cMRI. The detection of pathological findings due to myocarditis requires the determination of regional deformation parameters, particularly rCS and LV rotation. The assessment of global strain values does not appear to be of critical value.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1322145/fulltransthoracic echocardiogram (TTE)acute myocarditisdeformation imagingcardiac magnetic resonance imaginglongitudinal strain analysiscircumferential strain |
| spellingShingle | Joscha Kandels Sarah Richter Andreas Hagendorff Kristian Kragholm Kristian Kragholm Bhupendar Tayal Ulrich Laufs Timm Denecke Stephan Stöbe Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction Frontiers in Cardiovascular Medicine transthoracic echocardiogram (TTE) acute myocarditis deformation imaging cardiac magnetic resonance imaging longitudinal strain analysis circumferential strain |
| title | Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction |
| title_full | Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction |
| title_fullStr | Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction |
| title_full_unstemmed | Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction |
| title_short | Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction |
| title_sort | comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction |
| topic | transthoracic echocardiogram (TTE) acute myocarditis deformation imaging cardiac magnetic resonance imaging longitudinal strain analysis circumferential strain |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1322145/full |
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