Multiple subsets of regulatory T-cells
Regulatory T-lymphocytes play a central role in the immunological tolerance system. To date, existence of many different subpopulations of regulatory T-cells have been described. However, a number of questions related to the function, differentiation, and homeostasis of these subpopulations in a bod...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2020-10-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2999 |
| Summary: | Regulatory T-lymphocytes play a central role in the immunological tolerance system. To date, existence of many different subpopulations of regulatory T-cells have been described. However, a number of questions related to the function, differentiation, and homeostasis of these subpopulations in a body remain unclear. Interactions between the previously discovered pairs of helper and regulatory T-lymphocytes require further study. The main topic is identification and establishment of the functions of regulatory memory cells. Interstitial migration of activated regulatory T-lymphocytes is also a promising direction. In this review, we summarized the main findings in multiple subsets of regulatory T-lymphocytes, discussed unclear data that will require further studies, and showed an application for regulatory T-lymphocytes in medicine. |
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| ISSN: | 1682-0363 1819-3684 |