Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients
Background: The definition of World Health Organization (WHO) to the infertile couple is the failure of female get pregnancy in spite of having regular sexual activity for at least 1 year without using any contraceptive methods, worldwide it is estimated that 15 % of reproductive-age couples are st...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2023-07-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1053 |
| _version_ | 1797224034133344256 |
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| author | Essa Bahauldeen Fadhil Mohammed Mahmood Mohammed Ula M. Alkawaz |
| author_facet | Essa Bahauldeen Fadhil Mohammed Mahmood Mohammed Ula M. Alkawaz |
| author_sort | Essa Bahauldeen Fadhil |
| collection | DOAJ |
| description |
Background: The definition of World Health Organization (WHO) to the infertile couple is the failure of female get pregnancy in spite of having regular sexual activity for at least 1 year without using any contraceptive methods, worldwide it is estimated that 15 % of reproductive-age couples are struggling with infertility.
In many cases, infertility cannot be treated, new treatment options with promising value were involved in the recent clinical trials.
Aim: This study was designed to evaluate the effects of letrozole plus coenzyme Q10 combination on spermiogram and sex hormones in men with idiopathic oligoasthenoteratozoospermia (iOAT) syndrome.
Patient and methods: fifty-five patients are enrolled in this study, but only 40 patients complete the study, they are treated with a combination of Letrozole 2.5 mg tablet orally twice a week plus Co-enzyme Q10 400mg per day for three months. Seminal fluid sample, follicle-stimulating hormone, estradiol, and testosterone were analyzed before starting the treatment and at the end of month 1, 2 and 3.Results: sperm concentration, sperm morphology, total sperm count and motility, serum testosterone and follicle stimulation hormone levels, in addition to testosterone/estradiol ratio were significantly improved, while estradiol levels significantly decreased after 3 months of treatment. However, seminal fluid volume showed no significant change. Finally, as a notable outcome, one spontaneous conception occurred after treatment as well as three azoospermia cases responded well after completing the course of treatment.
Conclusions: a combination of Letrozole and CO Q10 can effectively improve sperm parameters in Iraqi men with iOAT.
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| first_indexed | 2024-04-24T13:46:42Z |
| format | Article |
| id | doaj.art-f75d645e844a4914a7f8d69b8607a3ea |
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| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:46:42Z |
| publishDate | 2023-07-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f75d645e844a4914a7f8d69b8607a3ea2024-04-04T06:20:52ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2023-07-0123310.32947/ajps.v23i3.1053Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patientsEssa Bahauldeen Fadhil 0Mohammed Mahmood Mohammed 1Ula M. Alkawaz 2Department of clinical pharmacy/College of Pharmacy/ Mustansiriyah University/ Baghdad, IraqDepartment of clinical pharmacy/College of Pharmacy/ Mustansiriyah University/ Baghdad, IraqHigh Institute of Infertility Diagnosis and Assisted Reproductive Technologies, Al-Nahrain University, Baghdad, Iraq Background: The definition of World Health Organization (WHO) to the infertile couple is the failure of female get pregnancy in spite of having regular sexual activity for at least 1 year without using any contraceptive methods, worldwide it is estimated that 15 % of reproductive-age couples are struggling with infertility. In many cases, infertility cannot be treated, new treatment options with promising value were involved in the recent clinical trials. Aim: This study was designed to evaluate the effects of letrozole plus coenzyme Q10 combination on spermiogram and sex hormones in men with idiopathic oligoasthenoteratozoospermia (iOAT) syndrome. Patient and methods: fifty-five patients are enrolled in this study, but only 40 patients complete the study, they are treated with a combination of Letrozole 2.5 mg tablet orally twice a week plus Co-enzyme Q10 400mg per day for three months. Seminal fluid sample, follicle-stimulating hormone, estradiol, and testosterone were analyzed before starting the treatment and at the end of month 1, 2 and 3.Results: sperm concentration, sperm morphology, total sperm count and motility, serum testosterone and follicle stimulation hormone levels, in addition to testosterone/estradiol ratio were significantly improved, while estradiol levels significantly decreased after 3 months of treatment. However, seminal fluid volume showed no significant change. Finally, as a notable outcome, one spontaneous conception occurred after treatment as well as three azoospermia cases responded well after completing the course of treatment. Conclusions: a combination of Letrozole and CO Q10 can effectively improve sperm parameters in Iraqi men with iOAT. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1053Male infertility, spermiogram, Letrozole, CO enzyme Q 10 |
| spellingShingle | Essa Bahauldeen Fadhil Mohammed Mahmood Mohammed Ula M. Alkawaz Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients Al-Mustansiriyah Journal of Pharmaceutical Sciences Male infertility, spermiogram, Letrozole, CO enzyme Q 10 |
| title | Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients |
| title_full | Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients |
| title_fullStr | Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients |
| title_full_unstemmed | Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients |
| title_short | Influence of Letrozole and Co Q10 on Sex Hormones and Spermiogram in Infertile Men; sample of Iraqi patients |
| title_sort | influence of letrozole and co q10 on sex hormones and spermiogram in infertile men sample of iraqi patients |
| topic | Male infertility, spermiogram, Letrozole, CO enzyme Q 10 |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1053 |
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