Dyslipidaemic Changes in Women with Subclinical Hypothyroidism
Background: In overt hypothyroidism, many lipid abnormalities have been documented. This study was intended to demonstrate the levels of lipid in women with subclinical hypothyroidism (SH). Material and Methods: This was a case control study which was done at referral Centre in Chennai. Women w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3448/5-%205777_E(C)_F(T)_PF1(Pr_P)_PFA(H)_PF2(Bo_PP).pdf |
| _version_ | 1818870439945961472 |
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| author | N. Karthick K.Dillara K.N. Poornima A.S. Subhasini |
| author_facet | N. Karthick K.Dillara K.N. Poornima A.S. Subhasini |
| author_sort | N. Karthick |
| collection | DOAJ |
| description | Background: In overt hypothyroidism, many lipid abnormalities
have been documented. This study was intended to demonstrate
the levels of lipid in women with subclinical hypothyroidism
(SH).
Material and Methods: This was a case control study which
was done at referral Centre in Chennai. Women with subclinical
hypothyroidism and euthyroid women attending our master
health checkup clinic were enrolled in this study.Their lipid profile,
fasting blood sugar, T3,T4 and TSH levels were measured. In
subclinical hypothyroidism, various parameters were compared.
Results: Thirty euthyroid and 30 age matched subclinical hypothyroid women were enrolled in this study. There were significant
dyslipidaemic changes is SH women as compared to euthyroid
controls. Serum total cholesterol and triglyceride levels were
significantly higher as compared to those in controls. LDL
levels were higher is SH women, but did not reach statistical
significance and lower levels of HDL were noticed in SH subjects
as compared to those in euthyroid women. A positive association
was also reported between serum TSH and lipid parameters in
our study group.
Conclusion: SH, the earliest form of thyroid failure, has negative
metabolic effects on the affected subjects. SH could be one of
the causes of secondary hyperlipidaemia and should be viewed as
an independent risk factor for atherosclerosis, along with obesity,
hypertension, diabetes, etc. |
| first_indexed | 2024-12-19T12:07:03Z |
| format | Article |
| id | doaj.art-f75f0e70074c45d48fa21bf514fd6f4e |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T12:07:03Z |
| publishDate | 2013-10-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-f75f0e70074c45d48fa21bf514fd6f4e2022-12-21T20:22:19ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-10-017102122212510.7860/JCDR/2013/5777.3448Dyslipidaemic Changes in Women with Subclinical HypothyroidismN. Karthick0K.Dillara1K.N. Poornima2A.S. Subhasini3Tutor, Department of Physiology, SRM Medical College Hospital & Research Centre, Potheri, Kanchipuram District, Tamilnadu, India.Professor, Department of Physiology, Sri Ramachandra Medical College, Porur, Chennai, Tamilnadu, India.Tutor, Department of Physiology, SRM Medical College Hospital & Research Centre, Potheri, Kanchipuram District, Tamilnadu, India.Professor, Department of Physiology, Sri Ramachandra Medical College, Porur, Chennai, Tamilnadu, India.Background: In overt hypothyroidism, many lipid abnormalities have been documented. This study was intended to demonstrate the levels of lipid in women with subclinical hypothyroidism (SH). Material and Methods: This was a case control study which was done at referral Centre in Chennai. Women with subclinical hypothyroidism and euthyroid women attending our master health checkup clinic were enrolled in this study.Their lipid profile, fasting blood sugar, T3,T4 and TSH levels were measured. In subclinical hypothyroidism, various parameters were compared. Results: Thirty euthyroid and 30 age matched subclinical hypothyroid women were enrolled in this study. There were significant dyslipidaemic changes is SH women as compared to euthyroid controls. Serum total cholesterol and triglyceride levels were significantly higher as compared to those in controls. LDL levels were higher is SH women, but did not reach statistical significance and lower levels of HDL were noticed in SH subjects as compared to those in euthyroid women. A positive association was also reported between serum TSH and lipid parameters in our study group. Conclusion: SH, the earliest form of thyroid failure, has negative metabolic effects on the affected subjects. SH could be one of the causes of secondary hyperlipidaemia and should be viewed as an independent risk factor for atherosclerosis, along with obesity, hypertension, diabetes, etc.https://jcdr.net/articles/PDF/3448/5-%205777_E(C)_F(T)_PF1(Pr_P)_PFA(H)_PF2(Bo_PP).pdfdyslipidaemiasubclinical hypothyroidismlipid profile |
| spellingShingle | N. Karthick K.Dillara K.N. Poornima A.S. Subhasini Dyslipidaemic Changes in Women with Subclinical Hypothyroidism Journal of Clinical and Diagnostic Research dyslipidaemia subclinical hypothyroidism lipid profile |
| title | Dyslipidaemic Changes in Women with Subclinical Hypothyroidism |
| title_full | Dyslipidaemic Changes in Women with Subclinical Hypothyroidism |
| title_fullStr | Dyslipidaemic Changes in Women with Subclinical Hypothyroidism |
| title_full_unstemmed | Dyslipidaemic Changes in Women with Subclinical Hypothyroidism |
| title_short | Dyslipidaemic Changes in Women with Subclinical Hypothyroidism |
| title_sort | dyslipidaemic changes in women with subclinical hypothyroidism |
| topic | dyslipidaemia subclinical hypothyroidism lipid profile |
| url | https://jcdr.net/articles/PDF/3448/5-%205777_E(C)_F(T)_PF1(Pr_P)_PFA(H)_PF2(Bo_PP).pdf |
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