Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer
The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These fin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1644598 |
| _version_ | 1797677183634767872 |
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| author | Gianluca Civenni Giuseppina M. Carbone Carlo V. Catapano |
| author_facet | Gianluca Civenni Giuseppina M. Carbone Carlo V. Catapano |
| author_sort | Gianluca Civenni |
| collection | DOAJ |
| description | The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These findings provide a new paradigm for developing novel treatment strategies for prostate cancer. |
| first_indexed | 2024-03-11T22:41:22Z |
| format | Article |
| id | doaj.art-f761285377c6439c840deaba4c2a4c43 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:22Z |
| publishDate | 2019-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-f761285377c6439c840deaba4c2a4c432023-09-22T09:11:00ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-09-016510.1080/23723556.2019.16445981644598Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancerGianluca Civenni0Giuseppina M. Carbone1Carlo V. Catapano2Università della Svizzera italiana (USI)Università della Svizzera italiana (USI)Università della Svizzera italiana (USI)The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These findings provide a new paradigm for developing novel treatment strategies for prostate cancer.http://dx.doi.org/10.1080/23723556.2019.1644598prostate cancercancer stem cellsbromodomain and extra-terminal domain proteinsbrd4mitochondrial fissionmffepigenetics |
| spellingShingle | Gianluca Civenni Giuseppina M. Carbone Carlo V. Catapano Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer Molecular & Cellular Oncology prostate cancer cancer stem cells bromodomain and extra-terminal domain proteins brd4 mitochondrial fission mff epigenetics |
| title | Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer |
| title_full | Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer |
| title_fullStr | Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer |
| title_full_unstemmed | Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer |
| title_short | Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer |
| title_sort | mitochondrial fission promotes self renewal and tumorigenic potential in prostate cancer |
| topic | prostate cancer cancer stem cells bromodomain and extra-terminal domain proteins brd4 mitochondrial fission mff epigenetics |
| url | http://dx.doi.org/10.1080/23723556.2019.1644598 |
| work_keys_str_mv | AT gianlucacivenni mitochondrialfissionpromotesselfrenewalandtumorigenicpotentialinprostatecancer AT giuseppinamcarbone mitochondrialfissionpromotesselfrenewalandtumorigenicpotentialinprostatecancer AT carlovcatapano mitochondrialfissionpromotesselfrenewalandtumorigenicpotentialinprostatecancer |