Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These fin...

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Bibliographic Details
Main Authors: Gianluca Civenni, Giuseppina M. Carbone, Carlo V. Catapano
Format: Article
Language:English
Published: Taylor & Francis Group 2019-09-01
Series:Molecular & Cellular Oncology
Subjects:
prostate cancer
cancer stem cells
bromodomain and extra-terminal domain proteins
brd4
mitochondrial fission
mff
epigenetics
Online Access:http://dx.doi.org/10.1080/23723556.2019.1644598

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