Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo
The purpose of this study was to find any association of the bovine growth hormone (bGH) gene with growth and carcass quality traits in Korean native cattle, Hanwoo. Genomic DNA was extracted from 21 Hanwoo individuals, and the 47 to 2,528 bp region of the bGH 2,856 bp (GenBank accession number M577...
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Asian-Australasian Association of Animal Production Societies
2013-10-01
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| Series: | Asian-Australasian Journal of Animal Sciences |
| Subjects: | |
| Online Access: | http://www.ajas.info/upload/pdf/ajas-26-10-1359-1.pdf |
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| author | Ji-Hong Lee Yun-Mi Lee Jea-Young Lee Dong-Yep Oh Dae-Jin Jeong Jong-Joo Kim |
| author_facet | Ji-Hong Lee Yun-Mi Lee Jea-Young Lee Dong-Yep Oh Dae-Jin Jeong Jong-Joo Kim |
| author_sort | Ji-Hong Lee |
| collection | DOAJ |
| description | The purpose of this study was to find any association of the bovine growth hormone (bGH) gene with growth and carcass quality traits in Korean native cattle, Hanwoo. Genomic DNA was extracted from 21 Hanwoo individuals, and the 47 to 2,528 bp region of the bGH 2,856 bp (GenBank accession number M57764) including the promoter and the five exons was sequenced. A total of ten bGH SNPs were confirmed, including four (253 C>T, 303 C>T, 502 C>T, and 559 G>A) in the promoter, one (679 C>T) in exon 1, one (1,692 T>C) in intron 3, and four (2141 C>G, 2258 C>T, 2277 C>T, and 2291 A>C) in exon 5. The ten bGH SNPs were genotyped for a sample of 242 Hanwoo steers and association tests were performed to find any significant SNP that was correlated with growth and carcass quality. Of the SNPs, the 303 C>T SNP in the promoter region was significantly associated with 6-month-old weight, the 559 G>A SNP with longissimus dorsi muscle area, the 2141 C>G SNP in exon 5 with daily weight gain, and the 2258 C>T SNP with daily weight gain and carcass weight (p<0.05). The significant SNPs need to be verified in other Hanwoo populations before considering implementation of marker-assisted selection for genetic improvement of growth and carcass quality in Hanwoo. |
| first_indexed | 2024-12-21T11:13:24Z |
| format | Article |
| id | doaj.art-f7622f93cc1f46b89ea42eb5e73fc966 |
| institution | Directory Open Access Journal |
| issn | 1011-2367 1976-5517 |
| language | English |
| last_indexed | 2024-12-21T11:13:24Z |
| publishDate | 2013-10-01 |
| publisher | Asian-Australasian Association of Animal Production Societies |
| record_format | Article |
| series | Asian-Australasian Journal of Animal Sciences |
| spelling | doaj.art-f7622f93cc1f46b89ea42eb5e73fc9662022-12-21T19:06:00ZengAsian-Australasian Association of Animal Production SocietiesAsian-Australasian Journal of Animal Sciences1011-23671976-55172013-10-0126101359136410.5713/ajas.2013.132484578Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in HanwooJi-Hong LeeYun-Mi LeeJea-Young LeeDong-Yep OhDae-Jin JeongJong-Joo KimThe purpose of this study was to find any association of the bovine growth hormone (bGH) gene with growth and carcass quality traits in Korean native cattle, Hanwoo. Genomic DNA was extracted from 21 Hanwoo individuals, and the 47 to 2,528 bp region of the bGH 2,856 bp (GenBank accession number M57764) including the promoter and the five exons was sequenced. A total of ten bGH SNPs were confirmed, including four (253 C>T, 303 C>T, 502 C>T, and 559 G>A) in the promoter, one (679 C>T) in exon 1, one (1,692 T>C) in intron 3, and four (2141 C>G, 2258 C>T, 2277 C>T, and 2291 A>C) in exon 5. The ten bGH SNPs were genotyped for a sample of 242 Hanwoo steers and association tests were performed to find any significant SNP that was correlated with growth and carcass quality. Of the SNPs, the 303 C>T SNP in the promoter region was significantly associated with 6-month-old weight, the 559 G>A SNP with longissimus dorsi muscle area, the 2141 C>G SNP in exon 5 with daily weight gain, and the 2258 C>T SNP with daily weight gain and carcass weight (p<0.05). The significant SNPs need to be verified in other Hanwoo populations before considering implementation of marker-assisted selection for genetic improvement of growth and carcass quality in Hanwoo.http://www.ajas.info/upload/pdf/ajas-26-10-1359-1.pdfBovine Growth Hormone GeneGrowth and Carcass TraitsHanwooSNP |
| spellingShingle | Ji-Hong Lee Yun-Mi Lee Jea-Young Lee Dong-Yep Oh Dae-Jin Jeong Jong-Joo Kim Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo Asian-Australasian Journal of Animal Sciences Bovine Growth Hormone Gene Growth and Carcass Traits Hanwoo SNP |
| title | Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo |
| title_full | Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo |
| title_fullStr | Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo |
| title_full_unstemmed | Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo |
| title_short | Identification of Single Nucleotide Polymorphisms (SNPs) of the Bovine Growth Hormone () Gene Associated with Growth and Carcass Traits in Hanwoo |
| title_sort | identification of single nucleotide polymorphisms snps of the bovine growth hormone gene associated with growth and carcass traits in hanwoo |
| topic | Bovine Growth Hormone Gene Growth and Carcass Traits Hanwoo SNP |
| url | http://www.ajas.info/upload/pdf/ajas-26-10-1359-1.pdf |
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