Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1,3-dione moiety as anticancer and antimicrobial agents

Synthesis, molecular docking study, and biological evaluation and of new thiadiazole and thiazole derivatives incorporating isoindoline-1,3-dione moiety as anticancer and antimicrobial agents

To highlight the importance of thiazole and thiadiazole derivatives in the progression of cancer and microbial treatments and to aid in drug design, we have synthesized a new series of 1,3,4-thiadiazole and 1,3-thiazole derivatives. These were created by a two-step reaction process: initially, 2-(4-...

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Bibliographic Details
Main Authors: Wafaa A. Mokbel, Mona A. Hosny, Sobhi M. Gomha, Magdi E.A. Zaki, Basant Farag, Ahmed F. El Farargy, Areej Al Bahir, Yasser H. Zaki
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Results in Chemistry
Subjects:
Isoindoline-1,3-dione
1,3,4-thiadiazoles
Coupling
Molecular docking
Anticancer and antimicrobial activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624000717

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