Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats
Background: Non-alcoholic fatty liver disease (NAFLD) includes a range of liver damage from early steatosis to cirrhosis. Although NAFLD prevalence in the world is increasing, but there is no effective treatment for it. Objective: The aim of this study was to evaluate the effect of combined extract...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2019-12-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-2279-en.html |
| _version_ | 1818716244090552320 |
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| author | Mojgan Mohammadifar Mohsen Taghizadeh Alireza Abed Ali Soltani Omidreza Tamtaji Tahereh Khamechian Alireza Hatami Sayyed Alireza Talaei |
| author_facet | Mojgan Mohammadifar Mohsen Taghizadeh Alireza Abed Ali Soltani Omidreza Tamtaji Tahereh Khamechian Alireza Hatami Sayyed Alireza Talaei |
| author_sort | Mojgan Mohammadifar |
| collection | DOAJ |
| description | Background: Non-alcoholic fatty liver disease (NAFLD) includes a range of liver damage from early steatosis to cirrhosis. Although NAFLD prevalence in the world is increasing, but there is no effective treatment for it.
Objective: The aim of this study was to evaluate the effect of combined extract of jujube, chicory and silymarin on NAFLD induced by high-fat diet (HFD) in rats.
Method: In this experimental study 40 male rats randomly were divided in two groups: a negative control group (n = 8) and a high-fat diet group (n = 32). After 4 months of feeding with HFD, rats were assigned into 4 groups (n = 8) including an HFD group and three groups receiving HFD and the extract at 100, 200 and 400 mg/kg for 2 months. Finally, lipid profile, liver enzymes activity and liver histology were investigated.
Results: High-fat diet increased cholesterol, triglyceride and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity hepatic enzymes and lipid accumulation in liver tissue. Receiving the extract improved lipid profile and hepatic enzyme activity, dose-dependently. Histopathology of liver confirmed the change induced by HFD and protective effect of extract.
Conclusion: Treatment with combined extracts of jujube, chicory and silymarin improves high-fat diet (HFD) induced NAFLD in rats. |
| first_indexed | 2024-12-17T19:16:10Z |
| format | Article |
| id | doaj.art-f769d5e7a2794d10afed251cb8e83b48 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T19:16:10Z |
| publishDate | 2019-12-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-f769d5e7a2794d10afed251cb8e83b482022-12-21T21:35:46ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582019-12-011872133142Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in RatsMojgan Mohammadifar0Mohsen Taghizadeh1Alireza Abed2Ali Soltani3Omidreza Tamtaji4Tahereh Khamechian5Alireza Hatami6Sayyed Alireza Talaei7 Biochemistry and Nutrition in Metabolic Diseases Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Biochemistry and Nutrition in Metabolic Diseases Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Biochemistry and Nutrition in Metabolic Diseases Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Department of Pathology, School of Medicine, Kashan University Medical Sciences, Kashan, Iran Barij Essence Medicinal Plants Research Center, Kashan, Iran Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran Background: Non-alcoholic fatty liver disease (NAFLD) includes a range of liver damage from early steatosis to cirrhosis. Although NAFLD prevalence in the world is increasing, but there is no effective treatment for it. Objective: The aim of this study was to evaluate the effect of combined extract of jujube, chicory and silymarin on NAFLD induced by high-fat diet (HFD) in rats. Method: In this experimental study 40 male rats randomly were divided in two groups: a negative control group (n = 8) and a high-fat diet group (n = 32). After 4 months of feeding with HFD, rats were assigned into 4 groups (n = 8) including an HFD group and three groups receiving HFD and the extract at 100, 200 and 400 mg/kg for 2 months. Finally, lipid profile, liver enzymes activity and liver histology were investigated. Results: High-fat diet increased cholesterol, triglyceride and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity hepatic enzymes and lipid accumulation in liver tissue. Receiving the extract improved lipid profile and hepatic enzyme activity, dose-dependently. Histopathology of liver confirmed the change induced by HFD and protective effect of extract. Conclusion: Treatment with combined extracts of jujube, chicory and silymarin improves high-fat diet (HFD) induced NAFLD in rats.http://jmp.ir/article-1-2279-en.html<i>cichorium intybus</i><i>silybum marianum</i><i>ziziphus jujuba</i>high-fat dietnon-alcoholic fatty liver disease |
| spellingShingle | Mojgan Mohammadifar Mohsen Taghizadeh Alireza Abed Ali Soltani Omidreza Tamtaji Tahereh Khamechian Alireza Hatami Sayyed Alireza Talaei Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats Journal of Medicinal Plants <i>cichorium intybus</i> <i>silybum marianum</i> <i>ziziphus jujuba</i> high-fat diet non-alcoholic fatty liver disease |
| title | Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats |
| title_full | Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats |
| title_fullStr | Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats |
| title_full_unstemmed | Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats |
| title_short | Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats |
| title_sort | effect of ziziphus jujuba mill cichorium intybus l and silybum marianum l gaertn combination extract on non alcoholic fatty liver disease in rats |
| topic | <i>cichorium intybus</i> <i>silybum marianum</i> <i>ziziphus jujuba</i> high-fat diet non-alcoholic fatty liver disease |
| url | http://jmp.ir/article-1-2279-en.html |
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