Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage
Introduction: Skin interventions have been implemented to reduce neonatal mortality, demonstrating the skin’s role in neonatal innate immunity. We examined the impact of birthweight and environmental conditions on skin integrity in infants receiving oil massage in rural Nepal. Methods: In a communit...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-01-01
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| Series: | Biomedicine Hub |
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| Online Access: | https://www.karger.com/Article/FullText/512274 |
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| author | Marty O. Visscher Aimee Summers Vivek Narendran Subarna Khatry Jeevan Sherchand Steven LeClerq Joanne Katz James Tielsch Luke Mullany |
| author_facet | Marty O. Visscher Aimee Summers Vivek Narendran Subarna Khatry Jeevan Sherchand Steven LeClerq Joanne Katz James Tielsch Luke Mullany |
| author_sort | Marty O. Visscher |
| collection | DOAJ |
| description | Introduction: Skin interventions have been implemented to reduce neonatal mortality, demonstrating the skin’s role in neonatal innate immunity. We examined the impact of birthweight and environmental conditions on skin integrity in infants receiving oil massage in rural Nepal. Methods: In a community-based cluster randomized controlled trial, 991 premature and full-term infants were grouped by birthweight as: (1) 920–1,560 g, (2) 1,570–2,450 g, (3) 2,460–2,990 g, and (4) 3,000–4,050 g and by high or low heat index (HI). Skin integrity was measured as erythema, rash, dryness, pH, protein concentration, and transepidermal water loss (TEWL). Results: Skin pH was higher for the smallest (group 1) than the largest infants (group 4) and higher for group 2 than 3 and 4. Arm and leg rash differed for all 4 groups, with the least amount of rash for the smallest babies. Erythema was lower for group 1 than all others. The lower day 1 values for pH, TEWL and protein at high versus low HI remained lower over 28 days. The pH reduction was faster at high HI. Erythema (arm, leg) was more severe at high HI. Rash severity was greater at high HI for arms and legs every day. Conclusions: Birthweight influenced the skin response to oil massage. The smallest infants had the lowermost skin irritation, suggesting diminished ability to mount an inflammatory response. High HI may be protective for premature infants in low resource settings. |
| first_indexed | 2024-12-16T09:39:59Z |
| format | Article |
| id | doaj.art-f76a07fd50184e86a4ef4328c0599e99 |
| institution | Directory Open Access Journal |
| issn | 2296-6870 |
| language | English |
| last_indexed | 2024-12-16T09:39:59Z |
| publishDate | 2021-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Biomedicine Hub |
| spelling | doaj.art-f76a07fd50184e86a4ef4328c0599e992022-12-21T22:36:18ZengKarger PublishersBiomedicine Hub2296-68702021-01-0161172410.1159/000512274512274Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil MassageMarty O. VisscherAimee SummersVivek NarendranSubarna KhatryJeevan SherchandSteven LeClerqJoanne KatzJames TielschLuke MullanyIntroduction: Skin interventions have been implemented to reduce neonatal mortality, demonstrating the skin’s role in neonatal innate immunity. We examined the impact of birthweight and environmental conditions on skin integrity in infants receiving oil massage in rural Nepal. Methods: In a community-based cluster randomized controlled trial, 991 premature and full-term infants were grouped by birthweight as: (1) 920–1,560 g, (2) 1,570–2,450 g, (3) 2,460–2,990 g, and (4) 3,000–4,050 g and by high or low heat index (HI). Skin integrity was measured as erythema, rash, dryness, pH, protein concentration, and transepidermal water loss (TEWL). Results: Skin pH was higher for the smallest (group 1) than the largest infants (group 4) and higher for group 2 than 3 and 4. Arm and leg rash differed for all 4 groups, with the least amount of rash for the smallest babies. Erythema was lower for group 1 than all others. The lower day 1 values for pH, TEWL and protein at high versus low HI remained lower over 28 days. The pH reduction was faster at high HI. Erythema (arm, leg) was more severe at high HI. Rash severity was greater at high HI for arms and legs every day. Conclusions: Birthweight influenced the skin response to oil massage. The smallest infants had the lowermost skin irritation, suggesting diminished ability to mount an inflammatory response. High HI may be protective for premature infants in low resource settings.https://www.karger.com/Article/FullText/512274skin barrierskin integritystratum corneuminfantneonatepremature infantskin phtransepidermal water losstopical natural oilmassageenvironmental conditions |
| spellingShingle | Marty O. Visscher Aimee Summers Vivek Narendran Subarna Khatry Jeevan Sherchand Steven LeClerq Joanne Katz James Tielsch Luke Mullany Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage Biomedicine Hub skin barrier skin integrity stratum corneum infant neonate premature infant skin ph transepidermal water loss topical natural oil massage environmental conditions |
| title | Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage |
| title_full | Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage |
| title_fullStr | Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage |
| title_full_unstemmed | Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage |
| title_short | Birthweight and Environmental Conditions Impact Skin Barrier Adaptation in Neonates Receiving Natural Oil Massage |
| title_sort | birthweight and environmental conditions impact skin barrier adaptation in neonates receiving natural oil massage |
| topic | skin barrier skin integrity stratum corneum infant neonate premature infant skin ph transepidermal water loss topical natural oil massage environmental conditions |
| url | https://www.karger.com/Article/FullText/512274 |
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