Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae.

Initiation factor eIF4G is a key regulator of eukaryotic protein synthesis, recognizing proteins bound at both ends of an mRNA to help recruit messages to the small (40S) ribosomal subunit. Notably, the genomes of a wide variety of eukaryotes encode multiple distinct variants of eIF4G. We found that...

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Bibliographic Details
Main Authors: Bryan K Clarkson, Wendy V Gilbert, Jennifer A Doudna
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2817733?pdf=render

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