Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients
Abstract Background Carotid intima media thickness (C-IMT) and aortic IMT (A-IMT) increase in adult and pediatric patients with diabetes mellitus (DM), respectively. In both age groups IMT is used for early detection of macrovascular complications. In adult DM patients, A-IMT is still not a routine...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Cardiovascular Ultrasound |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12947-018-0127-x |
| _version_ | 1819291706669924352 |
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| author | Ayse Selcan Koc Hilmi Erdem Sumbul |
| author_facet | Ayse Selcan Koc Hilmi Erdem Sumbul |
| author_sort | Ayse Selcan Koc |
| collection | DOAJ |
| description | Abstract Background Carotid intima media thickness (C-IMT) and aortic IMT (A-IMT) increase in adult and pediatric patients with diabetes mellitus (DM), respectively. In both age groups IMT is used for early detection of macrovascular complications. In adult DM patients, A-IMT is still not a routine examination and is not used frequently. We aimed to determine whether there is an increase in A-IMT values measured from abdominal aorta besides traditional C-IMT in patients with type II DM and to determine parameters closely related to A-IMT in the same patient group. Methods We included 114 type II DM patients and 100 healthy control subjects similar in age and sex in our study. Bilateral C-IMT and A-IMT values were measured by B-mode ultrasonography (USG) in addition to anamnesis, physical examination and routine examinations of all patients. Results When the clinical, demographic and laboratory data of patients with and without DM were compared, there was a high level of glucose and HbA1c and low hemoglobin levels in the DM patient group. All other parameters were found to be similar between the two groups. When the B-mode USG findings were examined, it was found that C-IMT and A-IMT were increased in patients with DM, with the A-IMT increase being more prominent. A-IMT values were found to be strongly and positively correlated with age, systolic blood pressure, blood urea nitrogen, DM onset time and HbA1c levels, and a negatively and significantly correlated with hemoglobin levels (p < 0.05, for each). In the regression model, the parameters correlating most closely with A-IMT were DM diagnosis onset time, HbA1c and hemoglobin levels (p = 0.001 and β = 0.353, p = 0.014 and β = 0.247 and p < 0.001 and β = − 0.406). Conclusions As in pediatric DM patients also in adult DM patients A-IMT can easily be measured with new model USG devices. A-IMT must be measured during abdominal USG which is routine in adult DM patients. A-IMT is an easy, reproducible and non-invasive parameter that may be used in the diagnosis of macrovascular complications of adult type II DM. |
| first_indexed | 2024-12-24T03:42:54Z |
| format | Article |
| id | doaj.art-f76aef6e35dc43ccb7a1f6c5a4250e64 |
| institution | Directory Open Access Journal |
| issn | 1476-7120 |
| language | English |
| last_indexed | 2024-12-24T03:42:54Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Ultrasound |
| spelling | doaj.art-f76aef6e35dc43ccb7a1f6c5a4250e642022-12-21T17:16:50ZengBMCCardiovascular Ultrasound1476-71202018-06-011611710.1186/s12947-018-0127-xIncreased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patientsAyse Selcan Koc0Hilmi Erdem Sumbul1Department of Radiology, University of Health Sciences - Adana Health Practices and Research CenterDepartment of Internal Medicine, University of Health Sciences - Adana Health Practices and Research CenterAbstract Background Carotid intima media thickness (C-IMT) and aortic IMT (A-IMT) increase in adult and pediatric patients with diabetes mellitus (DM), respectively. In both age groups IMT is used for early detection of macrovascular complications. In adult DM patients, A-IMT is still not a routine examination and is not used frequently. We aimed to determine whether there is an increase in A-IMT values measured from abdominal aorta besides traditional C-IMT in patients with type II DM and to determine parameters closely related to A-IMT in the same patient group. Methods We included 114 type II DM patients and 100 healthy control subjects similar in age and sex in our study. Bilateral C-IMT and A-IMT values were measured by B-mode ultrasonography (USG) in addition to anamnesis, physical examination and routine examinations of all patients. Results When the clinical, demographic and laboratory data of patients with and without DM were compared, there was a high level of glucose and HbA1c and low hemoglobin levels in the DM patient group. All other parameters were found to be similar between the two groups. When the B-mode USG findings were examined, it was found that C-IMT and A-IMT were increased in patients with DM, with the A-IMT increase being more prominent. A-IMT values were found to be strongly and positively correlated with age, systolic blood pressure, blood urea nitrogen, DM onset time and HbA1c levels, and a negatively and significantly correlated with hemoglobin levels (p < 0.05, for each). In the regression model, the parameters correlating most closely with A-IMT were DM diagnosis onset time, HbA1c and hemoglobin levels (p = 0.001 and β = 0.353, p = 0.014 and β = 0.247 and p < 0.001 and β = − 0.406). Conclusions As in pediatric DM patients also in adult DM patients A-IMT can easily be measured with new model USG devices. A-IMT must be measured during abdominal USG which is routine in adult DM patients. A-IMT is an easy, reproducible and non-invasive parameter that may be used in the diagnosis of macrovascular complications of adult type II DM.http://link.springer.com/article/10.1186/s12947-018-0127-xAortic intima-media thicknessMacrovascular complicationType II diabetes mellitus |
| spellingShingle | Ayse Selcan Koc Hilmi Erdem Sumbul Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients Cardiovascular Ultrasound Aortic intima-media thickness Macrovascular complication Type II diabetes mellitus |
| title | Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients |
| title_full | Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients |
| title_fullStr | Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients |
| title_full_unstemmed | Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients |
| title_short | Increased aortic intima-media thickness may be used to detect macrovascular complications in adult type II diabetes mellitus patients |
| title_sort | increased aortic intima media thickness may be used to detect macrovascular complications in adult type ii diabetes mellitus patients |
| topic | Aortic intima-media thickness Macrovascular complication Type II diabetes mellitus |
| url | http://link.springer.com/article/10.1186/s12947-018-0127-x |
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