Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study
Objective The aim of this study was to measure the level of interleukin-17A (IL-17A) in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and its relation to disease activity. Patients and methods A total of 100 patients suffering from RA were chosen from the outpatient clinic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-01-01
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| Series: | Egyptian Rheumatology and Rehabilitation |
| Subjects: | |
| Online Access: | http://www.err.eg.net/article.asp?issn=1110-161X;year=2015;volume=42;issue=4;spage=183;epage=187;aulast=Elhewala |
| _version_ | 1818620229062754304 |
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| author | Abd Elsamad I Elhewala Samar G Soliman Alaa A Labib Waleed A Mousa Dalia Salah |
| author_facet | Abd Elsamad I Elhewala Samar G Soliman Alaa A Labib Waleed A Mousa Dalia Salah |
| author_sort | Abd Elsamad I Elhewala |
| collection | DOAJ |
| description | Objective
The aim of this study was to measure the level of interleukin-17A (IL-17A) in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and its relation to disease activity.
Patients and methods
A total of 100 patients suffering from RA were chosen from the outpatient clinic, Department of Physical Medicine and Rehabilitation, Menoufia University Hospital. The patient group was divided into three subgroups - mild, moderate, and severe - according to the disease activity score. All patients were subjected to clinical, laboratory, and ultrasound evaluation and to measurement of IL-17A in the serum and synovial fluid by means of the enzyme-linked immunosorbent assay technique. Fifty healthy individuals were evaluated for IL-17A level in the blood, and served as the control group.
Results
The present study revealed an increase in serum (P = 3.1) and synovial fluid (P = 5.2) IL-17A levels in RA patients with increased disease activity. The ultrasound study showed an increase in serum IL-17A levels with increased erosion of the knee (P = 5.99) and wrist (P = 5.03). There was an increase in serum IL-17A with increased effusion of the knee (P = 22.6) and wrist (P = 33.3). There was an increase in serum IL-17A with increased synovial hypertrophy of the knee (P = 6.39), wrist (P = 12.23), and second metacarpophalangeal (MCP) (P = 53.34). Finally, there was an increase in the blood IL-17A level, dryness of the eye (P = 3.8), dryness of the mouth (P = 3.2), and number of subcutaneous nodules (P = 2.5).
Conclusion
In our study; the mean serum and synovial IL-17A levels were found in high titers in patients with disease activity, and with extra-articular manifestations like dry eyes, dry mouth, and subcutaneous nodules. Also erosions, synovial hypertrophy, and effusions were found with significantly high titers of IL-17A, denoting its usefulness as a measurement tool for high disease activity and destruction. Also targeting IL-17A may be useful as a treatment option for aggressive disease and for rheumatoid patients with poor prognosis. |
| first_indexed | 2024-12-16T17:50:03Z |
| format | Article |
| id | doaj.art-f76b7dea492f4089b402a7740318333d |
| institution | Directory Open Access Journal |
| issn | 1110-161X 2090-3235 |
| language | English |
| last_indexed | 2024-12-16T17:50:03Z |
| publishDate | 2015-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Rheumatology and Rehabilitation |
| spelling | doaj.art-f76b7dea492f4089b402a7740318333d2022-12-21T22:22:21ZengSpringerOpenEgyptian Rheumatology and Rehabilitation1110-161X2090-32352015-01-0142418318710.4103/1110-161X.168164Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound studyAbd Elsamad I ElhewalaSamar G SolimanAlaa A LabibWaleed A MousaDalia SalahObjective The aim of this study was to measure the level of interleukin-17A (IL-17A) in the serum and synovial fluid of patients with rheumatoid arthritis (RA) and its relation to disease activity. Patients and methods A total of 100 patients suffering from RA were chosen from the outpatient clinic, Department of Physical Medicine and Rehabilitation, Menoufia University Hospital. The patient group was divided into three subgroups - mild, moderate, and severe - according to the disease activity score. All patients were subjected to clinical, laboratory, and ultrasound evaluation and to measurement of IL-17A in the serum and synovial fluid by means of the enzyme-linked immunosorbent assay technique. Fifty healthy individuals were evaluated for IL-17A level in the blood, and served as the control group. Results The present study revealed an increase in serum (P = 3.1) and synovial fluid (P = 5.2) IL-17A levels in RA patients with increased disease activity. The ultrasound study showed an increase in serum IL-17A levels with increased erosion of the knee (P = 5.99) and wrist (P = 5.03). There was an increase in serum IL-17A with increased effusion of the knee (P = 22.6) and wrist (P = 33.3). There was an increase in serum IL-17A with increased synovial hypertrophy of the knee (P = 6.39), wrist (P = 12.23), and second metacarpophalangeal (MCP) (P = 53.34). Finally, there was an increase in the blood IL-17A level, dryness of the eye (P = 3.8), dryness of the mouth (P = 3.2), and number of subcutaneous nodules (P = 2.5). Conclusion In our study; the mean serum and synovial IL-17A levels were found in high titers in patients with disease activity, and with extra-articular manifestations like dry eyes, dry mouth, and subcutaneous nodules. Also erosions, synovial hypertrophy, and effusions were found with significantly high titers of IL-17A, denoting its usefulness as a measurement tool for high disease activity and destruction. Also targeting IL-17A may be useful as a treatment option for aggressive disease and for rheumatoid patients with poor prognosis.http://www.err.eg.net/article.asp?issn=1110-161X;year=2015;volume=42;issue=4;spage=183;epage=187;aulast=Elhewaladisease activity score, interleukin-17, rheumatoid arthritis, ultrasonography |
| spellingShingle | Abd Elsamad I Elhewala Samar G Soliman Alaa A Labib Waleed A Mousa Dalia Salah Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study Egyptian Rheumatology and Rehabilitation disease activity score, interleukin-17, rheumatoid arthritis, ultrasonography |
| title | Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study |
| title_full | Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study |
| title_fullStr | Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study |
| title_full_unstemmed | Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study |
| title_short | Interleukin-17 level in rheumatoid arthritis patients and its relation to disease activity: a clinical and ultrasound study |
| title_sort | interleukin 17 level in rheumatoid arthritis patients and its relation to disease activity a clinical and ultrasound study |
| topic | disease activity score, interleukin-17, rheumatoid arthritis, ultrasonography |
| url | http://www.err.eg.net/article.asp?issn=1110-161X;year=2015;volume=42;issue=4;spage=183;epage=187;aulast=Elhewala |
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