Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases
Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce th...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.859206/full |
| _version_ | 1818140025087328256 |
|---|---|
| author | Chao-Yue Sun Zuo-Liang Zheng Cun-Wu Chen Bao-Wei Lu Dong Liu |
| author_facet | Chao-Yue Sun Zuo-Liang Zheng Cun-Wu Chen Bao-Wei Lu Dong Liu |
| author_sort | Chao-Yue Sun |
| collection | DOAJ |
| description | Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of life, and induce premature death worldwide. Evidence is accumulating that the gut microbiota is inextricably associated with HFD-induced metabolic disorders, and dietary intervention of gut microbiota is an effective therapeutic strategy for these metabolic dysfunctions. Polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber that exhibit biological activities in the prevention and treatment of HFD-induced metabolic diseases. Of note, natural polysaccharides are among the most potent modulators of the gut microbiota composition. However, the prebiotics-like effects of polysaccharides in treating HFD-induced metabolic diseases remain elusive. In this review, we introduce the critical role of gut microbiota human health and HFD-induced metabolic disorders. Importantly, we review current knowledge about the role of natural polysaccharides in improving HFD-induced metabolic diseases by regulating gut microbiota. |
| first_indexed | 2024-12-11T10:37:25Z |
| format | Article |
| id | doaj.art-f76dda8def524a069d04b63e0af0886d |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-11T10:37:25Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f76dda8def524a069d04b63e0af0886d2022-12-22T01:10:40ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-03-011310.3389/fmicb.2022.859206859206Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic DiseasesChao-Yue Sun0Zuo-Liang Zheng1Cun-Wu Chen2Bao-Wei Lu3Dong Liu4College of Biological and Pharmaceutical Engineering, West Anhui University, Lu’an, ChinaSchool of Life Science, Jiaying University, Meizhou, ChinaCollege of Biological and Pharmaceutical Engineering, West Anhui University, Lu’an, ChinaCollege of Biological and Pharmaceutical Engineering, West Anhui University, Lu’an, ChinaCollege of Biological and Pharmaceutical Engineering, West Anhui University, Lu’an, ChinaUnhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of life, and induce premature death worldwide. Evidence is accumulating that the gut microbiota is inextricably associated with HFD-induced metabolic disorders, and dietary intervention of gut microbiota is an effective therapeutic strategy for these metabolic dysfunctions. Polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber that exhibit biological activities in the prevention and treatment of HFD-induced metabolic diseases. Of note, natural polysaccharides are among the most potent modulators of the gut microbiota composition. However, the prebiotics-like effects of polysaccharides in treating HFD-induced metabolic diseases remain elusive. In this review, we introduce the critical role of gut microbiota human health and HFD-induced metabolic disorders. Importantly, we review current knowledge about the role of natural polysaccharides in improving HFD-induced metabolic diseases by regulating gut microbiota.https://www.frontiersin.org/articles/10.3389/fmicb.2022.859206/fullhigh-fat dietmetabolic diseasesgut microbiotapolysaccharidesobesity |
| spellingShingle | Chao-Yue Sun Zuo-Liang Zheng Cun-Wu Chen Bao-Wei Lu Dong Liu Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases Frontiers in Microbiology high-fat diet metabolic diseases gut microbiota polysaccharides obesity |
| title | Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases |
| title_full | Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases |
| title_fullStr | Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases |
| title_full_unstemmed | Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases |
| title_short | Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases |
| title_sort | targeting gut microbiota with natural polysaccharides effective interventions against high fat diet induced metabolic diseases |
| topic | high-fat diet metabolic diseases gut microbiota polysaccharides obesity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.859206/full |
| work_keys_str_mv | AT chaoyuesun targetinggutmicrobiotawithnaturalpolysaccharideseffectiveinterventionsagainsthighfatdietinducedmetabolicdiseases AT zuoliangzheng targetinggutmicrobiotawithnaturalpolysaccharideseffectiveinterventionsagainsthighfatdietinducedmetabolicdiseases AT cunwuchen targetinggutmicrobiotawithnaturalpolysaccharideseffectiveinterventionsagainsthighfatdietinducedmetabolicdiseases AT baoweilu targetinggutmicrobiotawithnaturalpolysaccharideseffectiveinterventionsagainsthighfatdietinducedmetabolicdiseases AT dongliu targetinggutmicrobiotawithnaturalpolysaccharideseffectiveinterventionsagainsthighfatdietinducedmetabolicdiseases |