Next-Generation Computationally Designed Influenza Hemagglutinin Vaccines Protect against H5Nx Virus Infections

Next-Generation Computationally Designed Influenza Hemagglutinin Vaccines Protect against H5Nx Virus Infections

H5N1 COBRA hemagglutinin (HA) sequences, termed human COBRA-2 HA, were constructed through layering of HA sequences from viruses isolated from humans collected between 2004–2007 using only clade 2 strains. These COBRA HA proteins, when expressed on the surface of virus-like particles (VLP), elicited...

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Bibliographic Details
Main Authors: Ivette A. Nuñez, Ying Huang, Ted M. Ross
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pathogens
Subjects:
COBRA
influenza
H5N1
avian influenza vaccine
H5Nx vaccine
Online Access:https://www.mdpi.com/2076-0817/10/11/1352

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