Hallmarks of peripheral nerve function in bone regeneration
Abstract Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and nerves remains unclear. In this review, we outline the role of the peripheral nervous system (PNS) in bone regeneration following injury. We fir...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-01-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-022-00240-x |
| _version_ | 1797958848777027584 |
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| author | Ranyang Tao Bobin Mi Yiqiang Hu Sien Lin Yuan Xiong Xuan Lu Adriana C. Panayi Gang Li Guohui Liu |
| author_facet | Ranyang Tao Bobin Mi Yiqiang Hu Sien Lin Yuan Xiong Xuan Lu Adriana C. Panayi Gang Li Guohui Liu |
| author_sort | Ranyang Tao |
| collection | DOAJ |
| description | Abstract Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and nerves remains unclear. In this review, we outline the role of the peripheral nervous system (PNS) in bone regeneration following injury. We first introduce the conserved role of nerves in tissue regeneration in species ranging from amphibians to mammals. We then present the distribution of the PNS in the skeletal system under physiological conditions, fractures, or regeneration. Furthermore, we summarize the ways in which the PNS communicates with bone-lineage cells, the vasculature, and immune cells in the bone microenvironment. Based on this comprehensive and timely review, we conclude that the PNS regulates bone regeneration through neuropeptides or neurotransmitters and cells in the peripheral nerves. An in-depth understanding of the roles of peripheral nerves in bone regeneration will inform the development of new strategies based on bone-nerve crosstalk in promoting bone repair and regeneration. |
| first_indexed | 2024-04-11T00:24:38Z |
| format | Article |
| id | doaj.art-f77159a798294691997d8c18bcaec4fa |
| institution | Directory Open Access Journal |
| issn | 2095-6231 |
| language | English |
| last_indexed | 2024-04-11T00:24:38Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj.art-f77159a798294691997d8c18bcaec4fa2023-01-08T12:06:53ZengNature Publishing GroupBone Research2095-62312023-01-0111111810.1038/s41413-022-00240-xHallmarks of peripheral nerve function in bone regenerationRanyang Tao0Bobin Mi1Yiqiang Hu2Sien Lin3Yuan Xiong4Xuan Lu5Adriana C. Panayi6Gang Li7Guohui Liu8Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales HospitalDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales HospitalDivision of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Orthopaedics & Traumatology, Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales HospitalDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Skeletal tissue is highly innervated. Although different types of nerves have been recently identified in the bone, the crosstalk between bone and nerves remains unclear. In this review, we outline the role of the peripheral nervous system (PNS) in bone regeneration following injury. We first introduce the conserved role of nerves in tissue regeneration in species ranging from amphibians to mammals. We then present the distribution of the PNS in the skeletal system under physiological conditions, fractures, or regeneration. Furthermore, we summarize the ways in which the PNS communicates with bone-lineage cells, the vasculature, and immune cells in the bone microenvironment. Based on this comprehensive and timely review, we conclude that the PNS regulates bone regeneration through neuropeptides or neurotransmitters and cells in the peripheral nerves. An in-depth understanding of the roles of peripheral nerves in bone regeneration will inform the development of new strategies based on bone-nerve crosstalk in promoting bone repair and regeneration.https://doi.org/10.1038/s41413-022-00240-x |
| spellingShingle | Ranyang Tao Bobin Mi Yiqiang Hu Sien Lin Yuan Xiong Xuan Lu Adriana C. Panayi Gang Li Guohui Liu Hallmarks of peripheral nerve function in bone regeneration Bone Research |
| title | Hallmarks of peripheral nerve function in bone regeneration |
| title_full | Hallmarks of peripheral nerve function in bone regeneration |
| title_fullStr | Hallmarks of peripheral nerve function in bone regeneration |
| title_full_unstemmed | Hallmarks of peripheral nerve function in bone regeneration |
| title_short | Hallmarks of peripheral nerve function in bone regeneration |
| title_sort | hallmarks of peripheral nerve function in bone regeneration |
| url | https://doi.org/10.1038/s41413-022-00240-x |
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