Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats
Crocodile oil (CO) is rich in monounsaturated fatty acids and polyunsaturated fatty acids. The antioxidant activity and cognitive effect of monounsaturated fatty acids and polyunsaturated fatty acids have been largely reported. This work aimed to investigate the effect of CO on antioxidant activity...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/4/791 |
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| author | Krittika Srisuksai Kongphop Parunyakul Pitchaya Santativongchai Narumon Phaonakrop Sittiruk Roytrakul Phitsanu Tulayakul Wirasak Fungfuang |
| author_facet | Krittika Srisuksai Kongphop Parunyakul Pitchaya Santativongchai Narumon Phaonakrop Sittiruk Roytrakul Phitsanu Tulayakul Wirasak Fungfuang |
| author_sort | Krittika Srisuksai |
| collection | DOAJ |
| description | Crocodile oil (CO) is rich in monounsaturated fatty acids and polyunsaturated fatty acids. The antioxidant activity and cognitive effect of monounsaturated fatty acids and polyunsaturated fatty acids have been largely reported. This work aimed to investigate the effect of CO on antioxidant activity and cognitive function in rats. Twenty-one rats were divided into three treatment groups: (1) sterile water (NS), (2) 1 mL/kg of CO (NC1), and (3) 3 mL/kg of CO (NC3). Rats underwent oral gavage once daily for 8 weeks. CO treatment decreased the triglycerides level significantly compared with that in the NS group. CO had a free radical scavenging ability greater than that of olive oil but had no effect on levels of antioxidant markers in the brain. Expression of unique proteins in the CO-treatment group were correlated with the detoxification of hydrogen peroxide. Rats in the NC1 group had better memory function than rats in the NC3 group. Expression of unique proteins in the NC1 group was correlated with memory function. However, CO did not cause a decline in cognitive function in rats. CO can be an alternative dietary oil because it has a hypolipidemia effect and antioxidant activity. In addition, CO did not cause a negative effect on cognitive function. |
| first_indexed | 2024-03-11T08:50:23Z |
| format | Article |
| id | doaj.art-f77161a983d14579a1201eb5bfd50c9f |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T08:50:23Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-f77161a983d14579a1201eb5bfd50c9f2023-11-16T20:30:34ZengMDPI AGFoods2304-81582023-02-0112479110.3390/foods12040791Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in RatsKrittika Srisuksai0Kongphop Parunyakul1Pitchaya Santativongchai2Narumon Phaonakrop3Sittiruk Roytrakul4Phitsanu Tulayakul5Wirasak Fungfuang6Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, ThailandDepartment of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, ThailandBio—Veterinary Science (International Program), Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, ThailandFunctional Ingredient and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, ThailandFunctional Ingredient and Food Innovation Research Group, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, ThailandDepartment of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, ThailandDepartment of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, ThailandCrocodile oil (CO) is rich in monounsaturated fatty acids and polyunsaturated fatty acids. The antioxidant activity and cognitive effect of monounsaturated fatty acids and polyunsaturated fatty acids have been largely reported. This work aimed to investigate the effect of CO on antioxidant activity and cognitive function in rats. Twenty-one rats were divided into three treatment groups: (1) sterile water (NS), (2) 1 mL/kg of CO (NC1), and (3) 3 mL/kg of CO (NC3). Rats underwent oral gavage once daily for 8 weeks. CO treatment decreased the triglycerides level significantly compared with that in the NS group. CO had a free radical scavenging ability greater than that of olive oil but had no effect on levels of antioxidant markers in the brain. Expression of unique proteins in the CO-treatment group were correlated with the detoxification of hydrogen peroxide. Rats in the NC1 group had better memory function than rats in the NC3 group. Expression of unique proteins in the NC1 group was correlated with memory function. However, CO did not cause a decline in cognitive function in rats. CO can be an alternative dietary oil because it has a hypolipidemia effect and antioxidant activity. In addition, CO did not cause a negative effect on cognitive function.https://www.mdpi.com/2304-8158/12/4/791crocodile oilantioxidantcognitive functionhyperlipidemiarat |
| spellingShingle | Krittika Srisuksai Kongphop Parunyakul Pitchaya Santativongchai Narumon Phaonakrop Sittiruk Roytrakul Phitsanu Tulayakul Wirasak Fungfuang Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats Foods crocodile oil antioxidant cognitive function hyperlipidemia rat |
| title | Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats |
| title_full | Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats |
| title_fullStr | Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats |
| title_full_unstemmed | Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats |
| title_short | Antioxidant Activity of Crocodile Oil (<i>Crocodylus siamensis</i>) on Cognitive Function in Rats |
| title_sort | antioxidant activity of crocodile oil i crocodylus siamensis i on cognitive function in rats |
| topic | crocodile oil antioxidant cognitive function hyperlipidemia rat |
| url | https://www.mdpi.com/2304-8158/12/4/791 |
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