Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan
Background: Dermatophytes are the most common group of fungi causing fungal infections all over the world. They are classified into three main groups Trichophyton, Microsporum and Epidermophyton. Among these, Trichophyton has the highest prevalence rate (70-90%) as compared to the others. The global...
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| Format: | Article |
| Language: | English |
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Jinnah University for Women
2021-08-01
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| Series: | RADS Journal of Biological Research & Applied Science |
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| Online Access: | http://jbas.juw.edu.pk/index.php/JBAS/article/view/348 |
| _version_ | 1828939875789832192 |
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| author | Fatima Ismail Abdul Ghani Saba Akbar |
| author_facet | Fatima Ismail Abdul Ghani Saba Akbar |
| author_sort | Fatima Ismail |
| collection | DOAJ |
| description | Background: Dermatophytes are the most common group of fungi causing fungal infections all over the world. They are classified into three main groups Trichophyton, Microsporum and Epidermophyton. Among these, Trichophyton has the highest prevalence rate (70-90%) as compared to the others. The global emergence of fungal infections is varied due to the socio-economic conditions throughout the world. Developing countries, like Pakistan, are facing an increase in the number of dermatophytoses, including frequent relapses and treatment failures.
Objectives: The study have been conducted to identify the emerging fungal species, the role of commonly available antifungals such as azoles including voriconazole, ketoconazole, fluconazole and amphotericin B were used to determine the drug resistance among these species.
Methodology: Nine groups of dermatophytes and non-dermatophyte fungi isolated from the patients of tinea corporis, tinea cruris, tinea capitis and tinea pedis infections were analyzed for Phenotypic diversity, antifungal susceptibility and strains identification, was performed by cultural characteristics and microscopy.
Results: Nine groups of isolated fungal strains were identified as Trichophyton interdigitale, Trichophyton mentagrophyte, Trichophyton rubrum amongst dermatophytes class and Aspergillus terreus, Aspergillus verisocolor, Aspergillus niger, Acretonium sordidulum and Acremonium sclerotigenum of non-dermatophytes class.
Conclusion: The study revealed Trichophytone interdigitale group as more frequent dermatophytes. Whereas, among the antifungal drugs, fluconazole that targets the Erg 1 gene of ergosterol biosynthesis in fungi is less effective most common antifungal drugs available locally. |
| first_indexed | 2024-12-14T03:09:28Z |
| format | Article |
| id | doaj.art-f774315680114db0b9bb652e89de8c96 |
| institution | Directory Open Access Journal |
| issn | 2305-8722 2521-8573 |
| language | English |
| last_indexed | 2024-12-14T03:09:28Z |
| publishDate | 2021-08-01 |
| publisher | Jinnah University for Women |
| record_format | Article |
| series | RADS Journal of Biological Research & Applied Science |
| spelling | doaj.art-f774315680114db0b9bb652e89de8c962022-12-21T23:19:18ZengJinnah University for WomenRADS Journal of Biological Research & Applied Science2305-87222521-85732021-08-0112110.37962/jbas.v12i1.348Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, PakistanFatima Ismail0Abdul Ghani1Saba Akbar2Department of Biochemistry and Biotechnology, the Islamia University of Bahawalpur, Pakistan.Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Pakistan.Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Pakistan.Background: Dermatophytes are the most common group of fungi causing fungal infections all over the world. They are classified into three main groups Trichophyton, Microsporum and Epidermophyton. Among these, Trichophyton has the highest prevalence rate (70-90%) as compared to the others. The global emergence of fungal infections is varied due to the socio-economic conditions throughout the world. Developing countries, like Pakistan, are facing an increase in the number of dermatophytoses, including frequent relapses and treatment failures. Objectives: The study have been conducted to identify the emerging fungal species, the role of commonly available antifungals such as azoles including voriconazole, ketoconazole, fluconazole and amphotericin B were used to determine the drug resistance among these species. Methodology: Nine groups of dermatophytes and non-dermatophyte fungi isolated from the patients of tinea corporis, tinea cruris, tinea capitis and tinea pedis infections were analyzed for Phenotypic diversity, antifungal susceptibility and strains identification, was performed by cultural characteristics and microscopy. Results: Nine groups of isolated fungal strains were identified as Trichophyton interdigitale, Trichophyton mentagrophyte, Trichophyton rubrum amongst dermatophytes class and Aspergillus terreus, Aspergillus verisocolor, Aspergillus niger, Acretonium sordidulum and Acremonium sclerotigenum of non-dermatophytes class. Conclusion: The study revealed Trichophytone interdigitale group as more frequent dermatophytes. Whereas, among the antifungal drugs, fluconazole that targets the Erg 1 gene of ergosterol biosynthesis in fungi is less effective most common antifungal drugs available locally.http://jbas.juw.edu.pk/index.php/JBAS/article/view/348Antifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis. |
| spellingShingle | Fatima Ismail Abdul Ghani Saba Akbar Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan RADS Journal of Biological Research & Applied Science Antifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis. |
| title | Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan |
| title_full | Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan |
| title_fullStr | Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan |
| title_full_unstemmed | Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan |
| title_short | Emergence of Antifungal Azole Resistance in the Fungal Strains of Tinea corporis, Tinea capitis, Tinea cruris and Tinea pedis from the Locality of Southern Punjab, Pakistan |
| title_sort | emergence of antifungal azole resistance in the fungal strains of tinea corporis tinea capitis tinea cruris and tinea pedis from the locality of southern punjab pakistan |
| topic | Antifungal Drug Resistance, Azoles, Dermatomycosis, Filamentous fungi, Sensitive Phenotype, Sterol biosynthesis. |
| url | http://jbas.juw.edu.pk/index.php/JBAS/article/view/348 |
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