Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality
Purpose: In the present study, the possibility of predicting mortality with the change in coagulation parameters depending on the severity of Covid-19-associated pneumonia was investigated. Materials and Methods: A total of 137 patients with Covid-19-associated pneumonia were included in the study....
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| Format: | Article |
| Language: | English |
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Cukurova University
2021-06-01
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| Series: | Cukurova Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1518997 |
| _version_ | 1797911352591777792 |
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| author | Adem Kaya Begüm Şeyda Avci Hilmi Erdem Sümbül Hasan Yeşilağaç Hayri Çınar Tuba Turunç Önder Yeşiloğlu Ferhat İçme Nevzat Ünal |
| author_facet | Adem Kaya Begüm Şeyda Avci Hilmi Erdem Sümbül Hasan Yeşilağaç Hayri Çınar Tuba Turunç Önder Yeşiloğlu Ferhat İçme Nevzat Ünal |
| author_sort | Adem Kaya |
| collection | DOAJ |
| description | Purpose: In the present study, the possibility of predicting mortality with the change in coagulation parameters depending on the severity of Covid-19-associated pneumonia was investigated.
Materials and Methods: A total of 137 patients with Covid-19-associated pneumonia were included in the study. The patients were divided into three groups according to the severity of pneumonia as mild, moderate and severe. According to the severity of pneumonia, the parameters of complete blood count and the levels of biochemical parameters were compared between the groups. By examining blood parameters according to mortality, ROC analysis and regression analysis were performed to determine the net effect of these parameters on mortality.
Results: As the severity of pneumonia increased, Prothrombin time (PT), International normalized ratio (INR) and Activated partial thromboplastin time (aPTT) values were also increased, and a statistically significant difference was found between the groups in PT and INR values. PT, INR and aPTT levels were higher in cases with mortality. Mortality can be predicted with 93.5% sensitivity and 97.5% specificity. according to the >45.1 seconds(sec) cut-off value of the coagulation parameter (aPTT+PT.
Conclusion: The coagulation parameter (aPTT + PT), whose level increases secondarily to the increase in Covid-19-associated pneumonia severity, provides successful results in predicting mortality, and may be a parameter that we can recommend in clinical use. |
| first_indexed | 2024-04-10T11:40:18Z |
| format | Article |
| id | doaj.art-f775a73b8dfe4f78ac2903c05411d9a5 |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T11:40:18Z |
| publishDate | 2021-06-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-f775a73b8dfe4f78ac2903c05411d9a52023-02-15T16:17:36ZengCukurova UniversityCukurova Medical Journal2602-30402021-06-0146254054710.17826/cumj.86402348Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortalityAdem Kaya0Begüm Şeyda Avci1Hilmi Erdem Sümbül2Hasan Yeşilağaç3Hayri Çınar4Tuba Turunç5Önder Yeşiloğlu6Ferhat İçme7Nevzat Ünal8Health Science University, Adana City Research and Training Hospital, Department of Emergency MedicineHealth Science University, Adana City Research and Training Hospital, Department of Internal MedicineHealth Science University, Adana City Research and Training Hospital, Department of Internal MedicineBaşkent University, Faculty of Medicine, Department of Emergency MedicineHealth Science University, Adana City Research and Training Hospital, Department of Emergency MedicineHealth Science University, Adana City Research and Training Hospital, Department of Infectious DiseaseMuş State Hospital, Emergency Medicine ClinicAnkara City Hospital, Department of Emergency MedicineHealth Science University, Adana City Research and Training Hospital, Medical Microbiological LaboratoryPurpose: In the present study, the possibility of predicting mortality with the change in coagulation parameters depending on the severity of Covid-19-associated pneumonia was investigated. Materials and Methods: A total of 137 patients with Covid-19-associated pneumonia were included in the study. The patients were divided into three groups according to the severity of pneumonia as mild, moderate and severe. According to the severity of pneumonia, the parameters of complete blood count and the levels of biochemical parameters were compared between the groups. By examining blood parameters according to mortality, ROC analysis and regression analysis were performed to determine the net effect of these parameters on mortality. Results: As the severity of pneumonia increased, Prothrombin time (PT), International normalized ratio (INR) and Activated partial thromboplastin time (aPTT) values were also increased, and a statistically significant difference was found between the groups in PT and INR values. PT, INR and aPTT levels were higher in cases with mortality. Mortality can be predicted with 93.5% sensitivity and 97.5% specificity. according to the >45.1 seconds(sec) cut-off value of the coagulation parameter (aPTT+PT. Conclusion: The coagulation parameter (aPTT + PT), whose level increases secondarily to the increase in Covid-19-associated pneumonia severity, provides successful results in predicting mortality, and may be a parameter that we can recommend in clinical use.https://dergipark.org.tr/tr/download/article-file/1518997covid-19 enfeksiyonu,koagülasyonptzinrapttmortalitecovid-19 infectioncoagulationptinrapttmortality |
| spellingShingle | Adem Kaya Begüm Şeyda Avci Hilmi Erdem Sümbül Hasan Yeşilağaç Hayri Çınar Tuba Turunç Önder Yeşiloğlu Ferhat İçme Nevzat Ünal Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality Cukurova Medical Journal covid-19 enfeksiyonu, koagülasyon ptz inr aptt mortalite covid-19 infection coagulation pt inr aptt mortality |
| title | Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality |
| title_full | Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality |
| title_fullStr | Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality |
| title_full_unstemmed | Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality |
| title_short | Relationship between Covid-19-associated pneumonia severity with coagulopathy and mortality |
| title_sort | relationship between covid 19 associated pneumonia severity with coagulopathy and mortality |
| topic | covid-19 enfeksiyonu, koagülasyon ptz inr aptt mortalite covid-19 infection coagulation pt inr aptt mortality |
| url | https://dergipark.org.tr/tr/download/article-file/1518997 |
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