Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
Abstract Objectives Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asymptomatic and sympto...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Clinical & Translational Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cti2.1182 |
| _version_ | 1818282352412983296 |
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| author | Chuanhao Jiang Yali Wang Min Hu Lingjun Wen Chuan Wen Yang Wang Weihong Zhu Shi Tai Zhongbiao Jiang Kui Xiao Nuno Rodrigues Faria Erik De Clercq Junmei Xu Guangdi Li |
| author_facet | Chuanhao Jiang Yali Wang Min Hu Lingjun Wen Chuan Wen Yang Wang Weihong Zhu Shi Tai Zhongbiao Jiang Kui Xiao Nuno Rodrigues Faria Erik De Clercq Junmei Xu Guangdi Li |
| author_sort | Chuanhao Jiang |
| collection | DOAJ |
| description | Abstract Objectives Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asymptomatic and symptomatic patients infected with SARS‐CoV‐2. Methods We collected clinical, laboratory and epidemiological records of patients hospitalised in a coronavirus field hospital in Wuhan. We performed qualitative detection of anti‐SARS‐CoV‐2 immunoglobulin M (IgM) and immunoglobulin G (IgG) using archived blood samples. Results Of 214 patients with SARS‐CoV‐2, 26 (12%) were asymptomatic at hospital admission and during hospitalisation. Most asymptomatic patients were ≤ 60 years (96%) and females (65%) and had few comorbidities (< 16%). Serum levels of white and red blood cells were higher in asymptomatic than in symptomatic patients (P‐values < 0.05). During hospitalisation, IgG seroconversion was commonly observed in both asymptomatic and symptomatic patients (85% versus 94%, P‐value = 0.07); in contrast, IgM seroconversion was less common in asymptomatic than in symptomatic patients (31% versus 74%, P‐value < 0.001). The median time from the first virus‐positive screening to IgG or IgM seroconversion was significantly shorter in asymptomatic than in symptomatic patients (median: 7 versus 14 days, P‐value < 0.01). Furthermore, IgG/IgM seroconversion rates increased concomitantly with the clearance of SARS‐CoV‐2 in both asymptomatic and symptomatic patients. At the time of virus clearance, IgG/IgM titres and plasma neutralisation capacity were significantly lower in recovered asymptomatic than in recovered symptomatic patients (P‐values < 0.01). Conclusion Asymptomatic and symptomatic patients exhibited different kinetics of IgG/IgM responses to SARS‐CoV‐2. Asymptomatic patients may transmit SARS‐CoV‐2, highlighting the importance of early diagnosis and treatment. |
| first_indexed | 2024-12-13T00:19:39Z |
| format | Article |
| id | doaj.art-f776a0535d1342b19e9d418be44238f7 |
| institution | Directory Open Access Journal |
| issn | 2050-0068 |
| language | English |
| last_indexed | 2024-12-13T00:19:39Z |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical & Translational Immunology |
| spelling | doaj.art-f776a0535d1342b19e9d418be44238f72022-12-22T00:05:40ZengWileyClinical & Translational Immunology2050-00682020-01-0199n/an/a10.1002/cti2.1182Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)Chuanhao Jiang0Yali Wang1Min Hu2Lingjun Wen3Chuan Wen4Yang Wang5Weihong Zhu6Shi Tai7Zhongbiao Jiang8Kui Xiao9Nuno Rodrigues Faria10Erik De Clercq11Junmei Xu12Guangdi Li13Department of Laboratory Medicine The Second Xiangya Hospital Central South University Changsha ChinaHunan Provincial Key Laboratory of Clinical Epidemiology School of Public Health Central South University Changsha ChinaDepartment of Laboratory Medicine The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Laboratory Medicine The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Pediatrics The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Social Affairs The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Orthopedic Surgery The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Cardiology The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Radiology The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Pulmonary and Critical Care Medicine The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Zoology University of Oxford Oxford UKDepartment of Microbiology, Immunology and Transplantation Rega Institute for Medical Research KU Leuven Leuven BelgiumDepartment of Anesthesiology The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Laboratory Medicine The Second Xiangya Hospital Central South University Changsha ChinaAbstract Objectives Asymptomatic and symptomatic patients may transmit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), but their clinical features and immune responses remain largely unclear. We aimed to characterise the clinical features and immune responses of asymptomatic and symptomatic patients infected with SARS‐CoV‐2. Methods We collected clinical, laboratory and epidemiological records of patients hospitalised in a coronavirus field hospital in Wuhan. We performed qualitative detection of anti‐SARS‐CoV‐2 immunoglobulin M (IgM) and immunoglobulin G (IgG) using archived blood samples. Results Of 214 patients with SARS‐CoV‐2, 26 (12%) were asymptomatic at hospital admission and during hospitalisation. Most asymptomatic patients were ≤ 60 years (96%) and females (65%) and had few comorbidities (< 16%). Serum levels of white and red blood cells were higher in asymptomatic than in symptomatic patients (P‐values < 0.05). During hospitalisation, IgG seroconversion was commonly observed in both asymptomatic and symptomatic patients (85% versus 94%, P‐value = 0.07); in contrast, IgM seroconversion was less common in asymptomatic than in symptomatic patients (31% versus 74%, P‐value < 0.001). The median time from the first virus‐positive screening to IgG or IgM seroconversion was significantly shorter in asymptomatic than in symptomatic patients (median: 7 versus 14 days, P‐value < 0.01). Furthermore, IgG/IgM seroconversion rates increased concomitantly with the clearance of SARS‐CoV‐2 in both asymptomatic and symptomatic patients. At the time of virus clearance, IgG/IgM titres and plasma neutralisation capacity were significantly lower in recovered asymptomatic than in recovered symptomatic patients (P‐values < 0.01). Conclusion Asymptomatic and symptomatic patients exhibited different kinetics of IgG/IgM responses to SARS‐CoV‐2. Asymptomatic patients may transmit SARS‐CoV‐2, highlighting the importance of early diagnosis and treatment.https://doi.org/10.1002/cti2.1182COVID‐19IgGIgMimmune responsesSARS‐CoV‐2 |
| spellingShingle | Chuanhao Jiang Yali Wang Min Hu Lingjun Wen Chuan Wen Yang Wang Weihong Zhu Shi Tai Zhongbiao Jiang Kui Xiao Nuno Rodrigues Faria Erik De Clercq Junmei Xu Guangdi Li Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Clinical & Translational Immunology COVID‐19 IgG IgM immune responses SARS‐CoV‐2 |
| title | Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) |
| title_full | Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) |
| title_fullStr | Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) |
| title_full_unstemmed | Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) |
| title_short | Antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) |
| title_sort | antibody seroconversion in asymptomatic and symptomatic patients infected with severe acute respiratory syndrome coronavirus 2 sars cov 2 |
| topic | COVID‐19 IgG IgM immune responses SARS‐CoV‐2 |
| url | https://doi.org/10.1002/cti2.1182 |
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