Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake
Abstract Background A recent study has reported that incidence of chronic kidney disease (CKD) is higher in evacuees, but the molecular mechanism still remains unclear. One plausible hypothesis is a change in vascular function following to psychological distress. In order to assess molecular mechani...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-019-1651-0 |
| _version_ | 1828946656242958336 |
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| author | Ryosuke Fujii Hiroya Yamada Mirai Yamazaki Eiji Munetsuna Yoshitaka Ando Koji Ohashi Hiroaki Ishikawa Haruki Shimoda Kiyomi Sakata Akira Ogawa Seiichiro Kobayashi Koji Suzuki the RIAS study group |
| author_facet | Ryosuke Fujii Hiroya Yamada Mirai Yamazaki Eiji Munetsuna Yoshitaka Ando Koji Ohashi Hiroaki Ishikawa Haruki Shimoda Kiyomi Sakata Akira Ogawa Seiichiro Kobayashi Koji Suzuki the RIAS study group |
| author_sort | Ryosuke Fujii |
| collection | DOAJ |
| description | Abstract Background A recent study has reported that incidence of chronic kidney disease (CKD) is higher in evacuees, but the molecular mechanism still remains unclear. One plausible hypothesis is a change in vascular function following to psychological distress. In order to assess molecular mechanisms underlying this association, we examined whether cardiovascular disease (CVD)-associated miRNAs (miR-126, miR-197, and miR-223) were associated with CKD among Japanese elderly survivors after an earthquake. Methods We analyzed 1385 individuals (670 men and 715 women) who participated in a post-disaster health check-up after the Great East Japan Earthquake, which occurred in 2011. The check-up involved collection of information about lifestyle, clinical history, the degree of housing damage, and baseline measurement of the estimated glomerular filtration rate. Expression levels of miRNAs were determined using real-time polymerase chain reaction. Estimated glomerular filtration rate (eGFR) was calculated using sex, age, and serum creatinine. CKD was defined as eGFR < 60 ml/min/1.73m2. The multivariable regression analyses were performed to examine the associations between CVD-associated miRNAs and CKD after adjusting potential confounders. Results Mean age (standard deviation) of participants with normal kidney function and CKD was 62.7 (10.6) and 71.9 (8.1) years, respectively. Expression levels of these miRNAs in participants with CKD were significantly lower than normal kidney function (all p < 0.001). Even after adjusting for lifestyle, clinical profiles, and psychological distress, significant associations between three miRNAs and CKD still remained. A significant linear association between the cumulative score of these miRNAs and CKD was found (p = 0.04). Conclusions This cross-sectional study suggested that CVD-associated miRNAs were an important factor of CKD in an elderly Japanese population after earthquake. Future studies need to examine this association in longitudinal dataset. |
| first_indexed | 2024-12-14T05:14:52Z |
| format | Article |
| id | doaj.art-f776d7d1fc794c47a29efacda7d8f021 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-14T05:14:52Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f776d7d1fc794c47a29efacda7d8f0212022-12-21T23:15:51ZengBMCBMC Nephrology1471-23692019-12-012011710.1186/s12882-019-1651-0Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan EarthquakeRyosuke Fujii0Hiroya Yamada1Mirai Yamazaki2Eiji Munetsuna3Yoshitaka Ando4Koji Ohashi5Hiroaki Ishikawa6Haruki Shimoda7Kiyomi Sakata8Akira Ogawa9Seiichiro Kobayashi10Koji Suzuki11the RIAS study groupDepartment of Preventive Medical Sciences, Fujita Health University School of Medical SciencesDepartment of Hygiene, Fujita Health University School of MedicineDepartment of Clinical Biochemistry, Fujita Health University School of Medical SciencesDepartment of Biochemistry, Fujita Health University School of MedicineDepartment of Clinical Biochemistry, Fujita Health University School of Medical SciencesDepartment of Clinical Biochemistry, Fujita Health University School of Medical SciencesDepartment of Clinical Biochemistry, Fujita Health University School of Medical SciencesDepartment of Hygiene and Preventive Medicine, Iwate Medical UniversityDepartment of Hygiene and Preventive Medicine, Iwate Medical UniversityIwate Medical UniversityIwate Medical UniversityDepartment of Preventive Medical Sciences, Fujita Health University School of Medical SciencesAbstract Background A recent study has reported that incidence of chronic kidney disease (CKD) is higher in evacuees, but the molecular mechanism still remains unclear. One plausible hypothesis is a change in vascular function following to psychological distress. In order to assess molecular mechanisms underlying this association, we examined whether cardiovascular disease (CVD)-associated miRNAs (miR-126, miR-197, and miR-223) were associated with CKD among Japanese elderly survivors after an earthquake. Methods We analyzed 1385 individuals (670 men and 715 women) who participated in a post-disaster health check-up after the Great East Japan Earthquake, which occurred in 2011. The check-up involved collection of information about lifestyle, clinical history, the degree of housing damage, and baseline measurement of the estimated glomerular filtration rate. Expression levels of miRNAs were determined using real-time polymerase chain reaction. Estimated glomerular filtration rate (eGFR) was calculated using sex, age, and serum creatinine. CKD was defined as eGFR < 60 ml/min/1.73m2. The multivariable regression analyses were performed to examine the associations between CVD-associated miRNAs and CKD after adjusting potential confounders. Results Mean age (standard deviation) of participants with normal kidney function and CKD was 62.7 (10.6) and 71.9 (8.1) years, respectively. Expression levels of these miRNAs in participants with CKD were significantly lower than normal kidney function (all p < 0.001). Even after adjusting for lifestyle, clinical profiles, and psychological distress, significant associations between three miRNAs and CKD still remained. A significant linear association between the cumulative score of these miRNAs and CKD was found (p = 0.04). Conclusions This cross-sectional study suggested that CVD-associated miRNAs were an important factor of CKD in an elderly Japanese population after earthquake. Future studies need to examine this association in longitudinal dataset.https://doi.org/10.1186/s12882-019-1651-0Chronic kidney diseasemicroRNACardiovascular diseaseMolecular epidemiologyPopulation-based study |
| spellingShingle | Ryosuke Fujii Hiroya Yamada Mirai Yamazaki Eiji Munetsuna Yoshitaka Ando Koji Ohashi Hiroaki Ishikawa Haruki Shimoda Kiyomi Sakata Akira Ogawa Seiichiro Kobayashi Koji Suzuki the RIAS study group Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake BMC Nephrology Chronic kidney disease microRNA Cardiovascular disease Molecular epidemiology Population-based study |
| title | Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake |
| title_full | Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake |
| title_fullStr | Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake |
| title_full_unstemmed | Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake |
| title_short | Circulating microRNAs (miR-126, miR-197, and miR-223) are associated with chronic kidney disease among elderly survivors of the Great East Japan Earthquake |
| title_sort | circulating micrornas mir 126 mir 197 and mir 223 are associated with chronic kidney disease among elderly survivors of the great east japan earthquake |
| topic | Chronic kidney disease microRNA Cardiovascular disease Molecular epidemiology Population-based study |
| url | https://doi.org/10.1186/s12882-019-1651-0 |
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