Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF
Calcium (Ca<sup>2+</sup>) signaling plays a dichotomous role in cellular biology, controlling cell survival and proliferation on the one hand and cellular toxicity and cell death on the other. Store-operated Ca<sup>2+</sup> entry (SOCE) by CRAC channels represents a major pat...
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/8/1887 |
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| author | Inbal Dagan Raz Palty |
| author_facet | Inbal Dagan Raz Palty |
| author_sort | Inbal Dagan |
| collection | DOAJ |
| description | Calcium (Ca<sup>2+</sup>) signaling plays a dichotomous role in cellular biology, controlling cell survival and proliferation on the one hand and cellular toxicity and cell death on the other. Store-operated Ca<sup>2+</sup> entry (SOCE) by CRAC channels represents a major pathway for Ca<sup>2+</sup> entry in non-excitable cells. The CRAC channel has two key components, the endoplasmic reticulum Ca<sup>2+</sup> sensor stromal interaction molecule (STIM) and the plasma-membrane Ca<sup>2+</sup> channel Orai. Physical coupling between STIM and Orai opens the CRAC channel and the resulting Ca<sup>2+</sup> flux is regulated by a negative feedback mechanism of slow Ca<sup>2+</sup> dependent inactivation (SCDI). The identification of the SOCE-associated regulatory factor (SARAF) and investigations of its role in SCDI have led to new functional and molecular insights into how SOCE is controlled. In this review, we provide an overview of the functional and molecular mechanisms underlying SCDI and discuss how the interaction between SARAF, STIM1, and Orai1 shapes Ca<sup>2+</sup> signaling in cells. |
| first_indexed | 2024-03-10T08:56:04Z |
| format | Article |
| id | doaj.art-f7781e2259db47bf9b689a33750f9b18 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T08:56:04Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f7781e2259db47bf9b689a33750f9b182023-11-22T07:08:44ZengMDPI AGCells2073-44092021-07-01108188710.3390/cells10081887Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAFInbal Dagan0Raz Palty1Technion Integrated Cancer Center, Department of Biochemistry, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 31096, IsraelTechnion Integrated Cancer Center, Department of Biochemistry, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 31096, IsraelCalcium (Ca<sup>2+</sup>) signaling plays a dichotomous role in cellular biology, controlling cell survival and proliferation on the one hand and cellular toxicity and cell death on the other. Store-operated Ca<sup>2+</sup> entry (SOCE) by CRAC channels represents a major pathway for Ca<sup>2+</sup> entry in non-excitable cells. The CRAC channel has two key components, the endoplasmic reticulum Ca<sup>2+</sup> sensor stromal interaction molecule (STIM) and the plasma-membrane Ca<sup>2+</sup> channel Orai. Physical coupling between STIM and Orai opens the CRAC channel and the resulting Ca<sup>2+</sup> flux is regulated by a negative feedback mechanism of slow Ca<sup>2+</sup> dependent inactivation (SCDI). The identification of the SOCE-associated regulatory factor (SARAF) and investigations of its role in SCDI have led to new functional and molecular insights into how SOCE is controlled. In this review, we provide an overview of the functional and molecular mechanisms underlying SCDI and discuss how the interaction between SARAF, STIM1, and Orai1 shapes Ca<sup>2+</sup> signaling in cells.https://www.mdpi.com/2073-4409/10/8/1887store operated calcium entry (SOCE)STIM1SARAFOrai1CRAC channelslow calcium dependent inactivation (CDI) |
| spellingShingle | Inbal Dagan Raz Palty Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF Cells store operated calcium entry (SOCE) STIM1 SARAF Orai1 CRAC channel slow calcium dependent inactivation (CDI) |
| title | Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF |
| title_full | Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF |
| title_fullStr | Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF |
| title_full_unstemmed | Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF |
| title_short | Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF |
| title_sort | regulation of store operated ca sup 2 sup entry by saraf |
| topic | store operated calcium entry (SOCE) STIM1 SARAF Orai1 CRAC channel slow calcium dependent inactivation (CDI) |
| url | https://www.mdpi.com/2073-4409/10/8/1887 |
| work_keys_str_mv | AT inbaldagan regulationofstoreoperatedcasup2supentrybysaraf AT razpalty regulationofstoreoperatedcasup2supentrybysaraf |