Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis
Aim: The risk of venous thromboembolism (VTE) and arterial thrombosis events (ATE) and potential corresponding risk factors were assessed in patients with cancer diagnosed with COVID-19. Methods: Adults with cancer treated in community health systems who were diagnosed with COVID-19 in 2020 were eva...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Thrombosis Update |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666572724000026 |
| _version_ | 1797248316005679104 |
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| author | Jeanna Wallenta Law Chenan Zhang Danny Idyro James L. Weese Andrew Schrag Frank Wolf Thomas D. Brown |
| author_facet | Jeanna Wallenta Law Chenan Zhang Danny Idyro James L. Weese Andrew Schrag Frank Wolf Thomas D. Brown |
| author_sort | Jeanna Wallenta Law |
| collection | DOAJ |
| description | Aim: The risk of venous thromboembolism (VTE) and arterial thrombosis events (ATE) and potential corresponding risk factors were assessed in patients with cancer diagnosed with COVID-19. Methods: Adults with cancer treated in community health systems who were diagnosed with COVID-19 in 2020 were evaluated for absolute risk (risk) of ATE and VTE. Thrombotic events were ascertained in the 90-day window starting with COVID-19 diagnosis (index). ICD codes defined baseline comorbidities, COVID-19, and thrombotic events. Results: 7591 patients were included with median age of 67, 6% with cardiovascular disease (CVD), 4% with prior VTE, and 24% were hospitalized at index. Risk of ATE and VTE were 2.1% (95%CI: 1.8, 2.5) and 3.2% (95%CI: 2.8, 3.6), respectively. Patients with CVD had increased risk [ATE: 20.1% (95%CI: 16.7, 24.1); VTE: 4.9% (95%CI: 3.3, 7.3)] as did patients with prior VTE [ATE: 3.8% (95%CI: 2.2, 6.6; VTE: 20.5% (95%CI: 16.4, 25.3)] and patients hospitalized with ventilator support [(ATE: 5.7% (95%CI: 2.6, 11.8; VTE: 6.6% (95%CI: 3.2, 13.0)]. Incidence rates for ATE and VTE were 0.094 and 0.141 per person-year, respectively. Conclusions: This study of cancer patients, conducted in a time period prior to vaccine availability, found patients with CVD, prior VTE, and with higher severity of COVID-19 were at increased risk for ATE and VTE. Identifying patients most at risk can help to target interventions. |
| first_indexed | 2024-03-07T22:53:52Z |
| format | Article |
| id | doaj.art-f778326d75f44c80ac8cbd65edd27182 |
| institution | Directory Open Access Journal |
| issn | 2666-5727 |
| language | English |
| last_indexed | 2024-04-24T20:12:39Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Thrombosis Update |
| spelling | doaj.art-f778326d75f44c80ac8cbd65edd271822024-03-23T06:26:15ZengElsevierThrombosis Update2666-57272024-03-0114100160Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysisJeanna Wallenta Law0Chenan Zhang1Danny Idyro2James L. Weese3Andrew Schrag4Frank Wolf5Thomas D. Brown6Syapse, West Chester, PA USA; Corresponding author. Cancer Epidemiologist Syapse, 1442 Pottstown Pike, West Chester, PA 19380 USA.Syapse, West Chester, PA USASyapse, West Chester, PA USAAdvocate Aurora Health, USASyapse, West Chester, PA USASyapse, West Chester, PA USASyapse, West Chester, PA USAAim: The risk of venous thromboembolism (VTE) and arterial thrombosis events (ATE) and potential corresponding risk factors were assessed in patients with cancer diagnosed with COVID-19. Methods: Adults with cancer treated in community health systems who were diagnosed with COVID-19 in 2020 were evaluated for absolute risk (risk) of ATE and VTE. Thrombotic events were ascertained in the 90-day window starting with COVID-19 diagnosis (index). ICD codes defined baseline comorbidities, COVID-19, and thrombotic events. Results: 7591 patients were included with median age of 67, 6% with cardiovascular disease (CVD), 4% with prior VTE, and 24% were hospitalized at index. Risk of ATE and VTE were 2.1% (95%CI: 1.8, 2.5) and 3.2% (95%CI: 2.8, 3.6), respectively. Patients with CVD had increased risk [ATE: 20.1% (95%CI: 16.7, 24.1); VTE: 4.9% (95%CI: 3.3, 7.3)] as did patients with prior VTE [ATE: 3.8% (95%CI: 2.2, 6.6; VTE: 20.5% (95%CI: 16.4, 25.3)] and patients hospitalized with ventilator support [(ATE: 5.7% (95%CI: 2.6, 11.8; VTE: 6.6% (95%CI: 3.2, 13.0)]. Incidence rates for ATE and VTE were 0.094 and 0.141 per person-year, respectively. Conclusions: This study of cancer patients, conducted in a time period prior to vaccine availability, found patients with CVD, prior VTE, and with higher severity of COVID-19 were at increased risk for ATE and VTE. Identifying patients most at risk can help to target interventions.http://www.sciencedirect.com/science/article/pii/S2666572724000026COVID-19Venous thromboembolismArterial thrombosisThrombotic eventsCancerReal-world |
| spellingShingle | Jeanna Wallenta Law Chenan Zhang Danny Idyro James L. Weese Andrew Schrag Frank Wolf Thomas D. Brown Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis Thrombosis Update COVID-19 Venous thromboembolism Arterial thrombosis Thrombotic events Cancer Real-world |
| title | Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis |
| title_full | Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis |
| title_fullStr | Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis |
| title_full_unstemmed | Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis |
| title_short | Risk of arterial and venous thrombotic events among patients with cancer diagnosed with COVID-19: A real-world data analysis |
| title_sort | risk of arterial and venous thrombotic events among patients with cancer diagnosed with covid 19 a real world data analysis |
| topic | COVID-19 Venous thromboembolism Arterial thrombosis Thrombotic events Cancer Real-world |
| url | http://www.sciencedirect.com/science/article/pii/S2666572724000026 |
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