The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease
Thoracic aortic aneurysms and dissections (TAADs) involve dilation of the aortic wall that can lead to tearing or rupture. Progressive extracellular matrix (ECM) degradation is common in TAAD, regardless of the underlying cause. TAAD treatments typically target cellular signaling pathways, rather th...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Biomaterials and Biosystems |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666534423000016 |
| _version_ | 1827989234774966272 |
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| author | Jessica E. Wagenseil |
| author_facet | Jessica E. Wagenseil |
| author_sort | Jessica E. Wagenseil |
| collection | DOAJ |
| description | Thoracic aortic aneurysms and dissections (TAADs) involve dilation of the aortic wall that can lead to tearing or rupture. Progressive extracellular matrix (ECM) degradation is common in TAAD, regardless of the underlying cause. TAAD treatments typically target cellular signaling pathways, rather than the ECM itself, due to the complex assembly process and long half-life of ECM proteins. Compounds that stabilize the ECM are proposed as an alternative TAAD therapy that addresses the underlying cause of aortic wall failure, namely compromised structural integrity. Compounds are discussed that revisit historical approaches to maintain and preserve structural integrity of biological tissues. |
| first_indexed | 2024-04-10T00:16:06Z |
| format | Article |
| id | doaj.art-f77b51ad7e344a359b4d3ef1ea6ea92f |
| institution | Directory Open Access Journal |
| issn | 2666-5344 |
| language | English |
| last_indexed | 2024-04-10T00:16:06Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj.art-f77b51ad7e344a359b4d3ef1ea6ea92f2023-03-16T05:06:18ZengElsevierBiomaterials and Biosystems2666-53442023-03-019100072The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal diseaseJessica E. Wagenseil0Department of Mechanical Engineering and Materials Science, Washington University, One Brookings Dr., MSC 1185-208-125, St. Louis, MO 63130, USAThoracic aortic aneurysms and dissections (TAADs) involve dilation of the aortic wall that can lead to tearing or rupture. Progressive extracellular matrix (ECM) degradation is common in TAAD, regardless of the underlying cause. TAAD treatments typically target cellular signaling pathways, rather than the ECM itself, due to the complex assembly process and long half-life of ECM proteins. Compounds that stabilize the ECM are proposed as an alternative TAAD therapy that addresses the underlying cause of aortic wall failure, namely compromised structural integrity. Compounds are discussed that revisit historical approaches to maintain and preserve structural integrity of biological tissues.http://www.sciencedirect.com/science/article/pii/S2666534423000016 |
| spellingShingle | Jessica E. Wagenseil The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease Biomaterials and Biosystems |
| title | The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease |
| title_full | The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease |
| title_fullStr | The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease |
| title_full_unstemmed | The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease |
| title_short | The matrix reloaded – Addressing structural integrity of the aortic wall in aneurysmal disease |
| title_sort | matrix reloaded addressing structural integrity of the aortic wall in aneurysmal disease |
| url | http://www.sciencedirect.com/science/article/pii/S2666534423000016 |
| work_keys_str_mv | AT jessicaewagenseil thematrixreloadedaddressingstructuralintegrityoftheaorticwallinaneurysmaldisease AT jessicaewagenseil matrixreloadedaddressingstructuralintegrityoftheaorticwallinaneurysmaldisease |