Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis
Abstract Introduction Recently, studies on behavioral tic suppression techniques have gained popularity as opposed to pharmacological alternatives that often have potentially dangerous side effects. Differential Reinforcement of Other Behaviors therapy (DRO) is one such behavioral technique whose ef...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-023-03501-2 |
| _version_ | 1797363202216951808 |
|---|---|
| author | Zakaria Ahmed Mohamed Yang Xue Miaoshui Bai Hanyu Dong Feiyong Jia |
| author_facet | Zakaria Ahmed Mohamed Yang Xue Miaoshui Bai Hanyu Dong Feiyong Jia |
| author_sort | Zakaria Ahmed Mohamed |
| collection | DOAJ |
| description | Abstract Introduction Recently, studies on behavioral tic suppression techniques have gained popularity as opposed to pharmacological alternatives that often have potentially dangerous side effects. Differential Reinforcement of Other Behaviors therapy (DRO) is one such behavioral technique whose efficacy in tic suppression has been experimentally demonstrated albeit in studies with very few patients, and lacking statistical power. Here, we conducted a meta-analysis of these studies to improve their overall power and explore whether DRO intervention is really effective for tic suppression. Materials and methods PubMed, Embase, PsycINFO, and Cochrane Library were searched from inception to August 30, 2023. Only original interventional studies that examined the efficacy of DRO for tic suppression were included. Results A total of 8 no control interventional studies involving 79 children with tic disorders were recruited. Most of the children had moderate tic severity. The pooled mean Yale Global Tic Severity Scale (YGTSS) score was 24.64 (95% CI: 21.99 – 30.12, p = < 0.00001, I 2 = 87%). In terms of efficacy of the DRO technique for tic suppression, the results showed that DRO was effective in reducing tic frequency among the children. The pooled standardized mean difference (SMD) was -10.25 (95% CI: -14.71 – -5.79, p = < 0.00001) with I 2 = 94%. Conclusion In conclusion, this study revealed that DRO is potentially an effective tic suppression technique for temporarily managing tic disorder. It also showed that DRO could be employed for both moderate and severe tic disorders. However, the technique bears crucial limitations that limit its implementation outside of experimental settings. More studies are needed to address these limitations and improve its applicability in the real world. |
| first_indexed | 2024-03-08T16:17:53Z |
| format | Article |
| id | doaj.art-f77ce1d779f8438d861321200384fba6 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-08T16:17:53Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-f77ce1d779f8438d861321200384fba62024-01-07T12:31:37ZengBMCBMC Neurology1471-23772024-01-012411810.1186/s12883-023-03501-2Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysisZakaria Ahmed Mohamed0Yang Xue1Miaoshui Bai2Hanyu Dong3Feiyong Jia4Department of Developmental and Behavioral Pediatrics, The First Hospital of Jilin UniversityDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin UniversityDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin UniversityDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin UniversityDepartment of Developmental and Behavioral Pediatrics, The First Hospital of Jilin UniversityAbstract Introduction Recently, studies on behavioral tic suppression techniques have gained popularity as opposed to pharmacological alternatives that often have potentially dangerous side effects. Differential Reinforcement of Other Behaviors therapy (DRO) is one such behavioral technique whose efficacy in tic suppression has been experimentally demonstrated albeit in studies with very few patients, and lacking statistical power. Here, we conducted a meta-analysis of these studies to improve their overall power and explore whether DRO intervention is really effective for tic suppression. Materials and methods PubMed, Embase, PsycINFO, and Cochrane Library were searched from inception to August 30, 2023. Only original interventional studies that examined the efficacy of DRO for tic suppression were included. Results A total of 8 no control interventional studies involving 79 children with tic disorders were recruited. Most of the children had moderate tic severity. The pooled mean Yale Global Tic Severity Scale (YGTSS) score was 24.64 (95% CI: 21.99 – 30.12, p = < 0.00001, I 2 = 87%). In terms of efficacy of the DRO technique for tic suppression, the results showed that DRO was effective in reducing tic frequency among the children. The pooled standardized mean difference (SMD) was -10.25 (95% CI: -14.71 – -5.79, p = < 0.00001) with I 2 = 94%. Conclusion In conclusion, this study revealed that DRO is potentially an effective tic suppression technique for temporarily managing tic disorder. It also showed that DRO could be employed for both moderate and severe tic disorders. However, the technique bears crucial limitations that limit its implementation outside of experimental settings. More studies are needed to address these limitations and improve its applicability in the real world.https://doi.org/10.1186/s12883-023-03501-2EfficacyDROTic disorderTherapy |
| spellingShingle | Zakaria Ahmed Mohamed Yang Xue Miaoshui Bai Hanyu Dong Feiyong Jia Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis BMC Neurology Efficacy DRO Tic disorder Therapy |
| title | Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis |
| title_full | Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis |
| title_fullStr | Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis |
| title_full_unstemmed | Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis |
| title_short | Efficacy of differential reinforcement of other behaviors therapy for tic disorder: a meta-analysis |
| title_sort | efficacy of differential reinforcement of other behaviors therapy for tic disorder a meta analysis |
| topic | Efficacy DRO Tic disorder Therapy |
| url | https://doi.org/10.1186/s12883-023-03501-2 |
| work_keys_str_mv | AT zakariaahmedmohamed efficacyofdifferentialreinforcementofotherbehaviorstherapyforticdisorderametaanalysis AT yangxue efficacyofdifferentialreinforcementofotherbehaviorstherapyforticdisorderametaanalysis AT miaoshuibai efficacyofdifferentialreinforcementofotherbehaviorstherapyforticdisorderametaanalysis AT hanyudong efficacyofdifferentialreinforcementofotherbehaviorstherapyforticdisorderametaanalysis AT feiyongjia efficacyofdifferentialreinforcementofotherbehaviorstherapyforticdisorderametaanalysis |