Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study
Abstract Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood–brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32070-0 |
| _version_ | 1827974671996289024 |
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| author | Júlio César Garcia de Alencar Flávia Barreto Garcez Agnes Araujo Sardinha Pinto Lucas Oliveira Junqueira e Silva Lucas de Moraes Soler Shirley Steffany Muñoz Fernandez Victor Van Vaisberg Luz Marina Gomez Gomez Sandra Maria Lima Ribeiro Thiago Junqueira Avelino-Silva Heraldo Possolo Souza |
| author_facet | Júlio César Garcia de Alencar Flávia Barreto Garcez Agnes Araujo Sardinha Pinto Lucas Oliveira Junqueira e Silva Lucas de Moraes Soler Shirley Steffany Muñoz Fernandez Victor Van Vaisberg Luz Marina Gomez Gomez Sandra Maria Lima Ribeiro Thiago Junqueira Avelino-Silva Heraldo Possolo Souza |
| author_sort | Júlio César Garcia de Alencar |
| collection | DOAJ |
| description | Abstract Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood–brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients’ outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality). We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn’t develop delirium (p: 0.69). Levels S100B on admission did not predict delirium in acutely ill elderly patients. Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct). |
| first_indexed | 2024-04-09T19:58:08Z |
| format | Article |
| id | doaj.art-f781dd925ac3480084973d6784eb08f8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T19:58:08Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f781dd925ac3480084973d6784eb08f82023-04-03T05:22:40ZengNature PortfolioScientific Reports2045-23222023-03-011311810.1038/s41598-023-32070-0Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort studyJúlio César Garcia de Alencar0Flávia Barreto Garcez1Agnes Araujo Sardinha Pinto2Lucas Oliveira Junqueira e Silva3Lucas de Moraes Soler4Shirley Steffany Muñoz Fernandez5Victor Van Vaisberg6Luz Marina Gomez Gomez7Sandra Maria Lima Ribeiro8Thiago Junqueira Avelino-Silva9Heraldo Possolo Souza10Disciplina de Emergências Clínicas, Faculdade de Medicina, Universidade de São PauloHospital Universitário, Departamento de Medicina, Universidade Federal de SergipeDisciplina de Emergências Clínicas, Faculdade de Medicina, Universidade de São PauloHospital de Cínicas de Porto Alegre, Universidade Federal do Rio Grande do SulDisciplina de Nefrologia, Faculdade de Medicina de Botucatu, Universidade Estadual de São PauloDepartamento de Nutrição, Faculdade de Saúde Pública, Universidade de São PauloDisciplina de Emergências Clínicas, Faculdade de Medicina, Universidade de São PauloDisciplina de Emergências Clínicas, Faculdade de Medicina, Universidade de São PauloDepartamento de Nutrição, Faculdade de Saúde Pública, Universidade de São PauloFaculdade Israelita de Ciências da Saúde Albert Einstein, Hospital Israelita Albert EinsteinDisciplina de Emergências Clínicas, Faculdade de Medicina, Universidade de São PauloAbstract Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood–brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients’ outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality). We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn’t develop delirium (p: 0.69). Levels S100B on admission did not predict delirium in acutely ill elderly patients. Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct).https://doi.org/10.1038/s41598-023-32070-0 |
| spellingShingle | Júlio César Garcia de Alencar Flávia Barreto Garcez Agnes Araujo Sardinha Pinto Lucas Oliveira Junqueira e Silva Lucas de Moraes Soler Shirley Steffany Muñoz Fernandez Victor Van Vaisberg Luz Marina Gomez Gomez Sandra Maria Lima Ribeiro Thiago Junqueira Avelino-Silva Heraldo Possolo Souza Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study Scientific Reports |
| title | Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
| title_full | Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
| title_fullStr | Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
| title_full_unstemmed | Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
| title_short | Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study |
| title_sort | brain injury biomarkers do not predict delirium in acutely ill older patients a prospective cohort study |
| url | https://doi.org/10.1038/s41598-023-32070-0 |
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