The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma
Abstract Background Endometrial carcinoma is a common malignant tumor in female reproductive system. At present, there is no effective and economic prognostic index. This study aimed to investigate the effect of serum ferritin levels on the prognosis of endometrial carcinoma. Methods Data of 367 pat...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Women's Health |
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| Online Access: | https://doi.org/10.1186/s12905-023-02575-x |
| _version_ | 1797451656803123200 |
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| author | Jiali Liu Beibei Xuan Quan Quan Sainan Gong Xiaoling Mu |
| author_facet | Jiali Liu Beibei Xuan Quan Quan Sainan Gong Xiaoling Mu |
| author_sort | Jiali Liu |
| collection | DOAJ |
| description | Abstract Background Endometrial carcinoma is a common malignant tumor in female reproductive system. At present, there is no effective and economic prognostic index. This study aimed to investigate the effect of serum ferritin levels on the prognosis of endometrial carcinoma. Methods Data of 367 patients who diagnosed with endometrial carcinoma at the First Affiliated Hospital of Chongqing Medical University between January 2012 and August 2018 was retrospectively analyzed. The prediction accuracy was evaluated by receiver operating characteristics curves and Youden's J statistics. Hosmer–lemeshow test was used to confirm the goodness of fit of the model. The prognostic value of serum ferritin on disease free survival (DFS) and overall survival (OS) of endometrial carcinoma was evaluated by univariate log-rank tests and multivariate cox regression models. Results Preoperative high serum ferritin was correlated with older age, high grade, specific histological subtypes and recurrence of endometrial carcinoma (P < 0.05). The DFS and OS of 198 patients with elevated serum ferritin levels were significantly lower than those with low serum ferritin levels (P = 0.001 and P = 0.002, respectively). In multivariate analysis, serum ferritin was an independent prognostic factor for DFS and OS in endometrial carcinoma (P = 0.012, P = 0.028). Conclusion Through our research, we found that the high expression of serum ferritin level was not only related to low DFS and OS in patients with endometrial carcinoma, but also related to the high-risk factors of endometrial carcinoma recurrence. So serum ferritin levels may be used to predict the poor prognosis of patients with endometrial carcinoma. |
| first_indexed | 2024-03-09T14:57:38Z |
| format | Article |
| id | doaj.art-f782a786070045798b44b6654bdff7f8 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-09T14:57:38Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-f782a786070045798b44b6654bdff7f82023-11-26T14:06:53ZengBMCBMC Women's Health1472-68742023-08-012311910.1186/s12905-023-02575-xThe crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinomaJiali Liu0Beibei Xuan1Quan Quan2Sainan Gong3Xiaoling Mu4Department of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Background Endometrial carcinoma is a common malignant tumor in female reproductive system. At present, there is no effective and economic prognostic index. This study aimed to investigate the effect of serum ferritin levels on the prognosis of endometrial carcinoma. Methods Data of 367 patients who diagnosed with endometrial carcinoma at the First Affiliated Hospital of Chongqing Medical University between January 2012 and August 2018 was retrospectively analyzed. The prediction accuracy was evaluated by receiver operating characteristics curves and Youden's J statistics. Hosmer–lemeshow test was used to confirm the goodness of fit of the model. The prognostic value of serum ferritin on disease free survival (DFS) and overall survival (OS) of endometrial carcinoma was evaluated by univariate log-rank tests and multivariate cox regression models. Results Preoperative high serum ferritin was correlated with older age, high grade, specific histological subtypes and recurrence of endometrial carcinoma (P < 0.05). The DFS and OS of 198 patients with elevated serum ferritin levels were significantly lower than those with low serum ferritin levels (P = 0.001 and P = 0.002, respectively). In multivariate analysis, serum ferritin was an independent prognostic factor for DFS and OS in endometrial carcinoma (P = 0.012, P = 0.028). Conclusion Through our research, we found that the high expression of serum ferritin level was not only related to low DFS and OS in patients with endometrial carcinoma, but also related to the high-risk factors of endometrial carcinoma recurrence. So serum ferritin levels may be used to predict the poor prognosis of patients with endometrial carcinoma.https://doi.org/10.1186/s12905-023-02575-xEndometrial carcinomaSerum ferritinInflammationFerroptosis |
| spellingShingle | Jiali Liu Beibei Xuan Quan Quan Sainan Gong Xiaoling Mu The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma BMC Women's Health Endometrial carcinoma Serum ferritin Inflammation Ferroptosis |
| title | The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma |
| title_full | The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma |
| title_fullStr | The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma |
| title_full_unstemmed | The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma |
| title_short | The crucial value of serum ferritin in assessing high-risk factors and prognosis for patients with endometrial carcinoma |
| title_sort | crucial value of serum ferritin in assessing high risk factors and prognosis for patients with endometrial carcinoma |
| topic | Endometrial carcinoma Serum ferritin Inflammation Ferroptosis |
| url | https://doi.org/10.1186/s12905-023-02575-x |
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