Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans.

Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans.

The normal aging process is associated with stereotyped changes in gene expression, but the regulators responsible for these age-dependent changes are poorly understood. Using a novel genomics approach, we identified HOX co-factor unc-62 (Homothorax) as a developmental regulator that binds proximal...

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Bibliographic Details
Main Authors: Eric L Van Nostrand, Adolfo Sánchez-Blanco, Beijing Wu, Andy Nguyen, Stuart K Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3585033?pdf=render

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