LRP5, Bone Density, and Mechanical Stress: A Case Report and Literature Review

LRP5, Bone Density, and Mechanical Stress: A Case Report and Literature Review

The Wnt-β-catenin pathway receptor, low-density lipoprotein receptor-related protein 5 (LRP5), is a known regulator of bone mineral density. It has been hypothesized that specific human polymorphisms in LRP5 impact bone density, in part, by altering the anabolic response of bone to mechanical loadin...

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Bibliographic Details
Main Authors: Nicholas G. Norwitz, Adrian Soto Mota, Madhusmita Misra, Kathryn E. Ackerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Endocrinology
Subjects:
bone mineral density
LRP5
mechanical stress
osteoporosis
Wnt-β-catenin signaling
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00184/full

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