Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER
Michael Birnbaum1, Zafar Sharif21St. Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Ave, New York, NY, USA; 2Columbia University College of Physicians and Surgeons, New York, NY, USAAbstract: Antipsychotic medications provide the foundation for treatment of acute exacerbations as wel...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2008-12-01
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| Series: | Patient Preference and Adherence |
| Online Access: | http://www.dovepress.com/medication-adherence-in-schizophrenia-patient-perspectives-and-the-cli-a2751 |
| _version_ | 1818927139270950912 |
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| author | Michael Birnbaum Zafar Sharif |
| author_facet | Michael Birnbaum Zafar Sharif |
| author_sort | Michael Birnbaum |
| collection | DOAJ |
| description | Michael Birnbaum1, Zafar Sharif21St. Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Ave, New York, NY, USA; 2Columbia University College of Physicians and Surgeons, New York, NY, USAAbstract: Antipsychotic medications provide the foundation for treatment of acute exacerbations as well as relapse prevention in patients with schizophrenia as demonstrated by rigorous placebo-controlled trials. However, despite their proven effectiveness, poor adherence to prescribed antipsychotic regimens remains the most important driver of suboptimal clinical outcomes in this population. This paper reviews the magnitude of the problem of medication non-adherence in patients with schizophrenia and the various factors that contribute to nonadherence, with particular emphasis on factors related to antipsychotic medications. The profile of the latest atypical antipsychotic, paliperidone extended-release (ER) tablets, is then reviewed and the implications of its unique pharmacokinetic profile for adherence in this patient population are discussed.Keywords: schizophrenia, adherence, paliperidone, pharmacokinetics |
| first_indexed | 2024-12-20T03:08:16Z |
| format | Article |
| id | doaj.art-f78565fe840d478ba359c8b83eda81e0 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-20T03:08:16Z |
| publishDate | 2008-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-f78565fe840d478ba359c8b83eda81e02022-12-21T19:55:32ZengDove Medical PressPatient Preference and Adherence1177-889X2008-12-012008default233240Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ERMichael BirnbaumZafar SharifMichael Birnbaum1, Zafar Sharif21St. Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Ave, New York, NY, USA; 2Columbia University College of Physicians and Surgeons, New York, NY, USAAbstract: Antipsychotic medications provide the foundation for treatment of acute exacerbations as well as relapse prevention in patients with schizophrenia as demonstrated by rigorous placebo-controlled trials. However, despite their proven effectiveness, poor adherence to prescribed antipsychotic regimens remains the most important driver of suboptimal clinical outcomes in this population. This paper reviews the magnitude of the problem of medication non-adherence in patients with schizophrenia and the various factors that contribute to nonadherence, with particular emphasis on factors related to antipsychotic medications. The profile of the latest atypical antipsychotic, paliperidone extended-release (ER) tablets, is then reviewed and the implications of its unique pharmacokinetic profile for adherence in this patient population are discussed.Keywords: schizophrenia, adherence, paliperidone, pharmacokineticshttp://www.dovepress.com/medication-adherence-in-schizophrenia-patient-perspectives-and-the-cli-a2751 |
| spellingShingle | Michael Birnbaum Zafar Sharif Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER Patient Preference and Adherence |
| title | Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER |
| title_full | Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER |
| title_fullStr | Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER |
| title_full_unstemmed | Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER |
| title_short | Medication adherence in schizophrenia: patient perspectives and the clinical utility of paliperidone ER |
| title_sort | medication adherence in schizophrenia patient perspectives and the clinical utility of paliperidone er |
| url | http://www.dovepress.com/medication-adherence-in-schizophrenia-patient-perspectives-and-the-cli-a2751 |
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