Diuretic resistance and the role of albumin in congestive heart failure
Diuresis with loop diuretics is the mainstay treatment for volume optimization in patients with congestive heart failure, in which perfusion and volume expansion play a crucial role. There are robust guidelines with extensive evidence for the management of heart failure; however, clear guidance is n...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BioExcel Publishing Ltd
2023-12-01
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| Series: | Drugs in Context |
| Subjects: | |
| Online Access: | https://www.drugsincontext.com/diuretic-resistance-and-the-role-of-albumin-in-congestive-heart-failure/ |
| _version_ | 1797372406693625856 |
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| author | Carol Fernandez Hazim Gustavo Duarte Ana P Urena Swati Jain Rishabh Mishra Timothy J Vittorio Miguel Rodriguez-Guerra |
| author_facet | Carol Fernandez Hazim Gustavo Duarte Ana P Urena Swati Jain Rishabh Mishra Timothy J Vittorio Miguel Rodriguez-Guerra |
| author_sort | Carol Fernandez Hazim |
| collection | DOAJ |
| description | Diuresis with loop diuretics is the mainstay treatment for volume optimization in patients with congestive heart failure, in which perfusion and volume expansion play a crucial role. There are robust guidelines with extensive evidence for the management of heart failure; however, clear guidance is needed for patients who do not respond to standard diuretic treatment. Diuretic resistance (DR) can be defined as an insufficient quantity of natriuresis with proper diuretic therapy. A combination of diuretic regimens is used to overcome DR and, more recently, SGLT2 inhibitors have been shown to improve diuresis. Despite DR being relatively common, it is challenging to treat and there remains a notable lack of substantial data guiding its management. Moreover, DR has been linked with poor prognosis. This review aims to expose the multiple approaches for treatment of patients with DR and the importance of intravascular volume expansion in the response to therapy. |
| first_indexed | 2024-03-08T18:35:22Z |
| format | Article |
| id | doaj.art-f78783fcedfa42df86d332695423703d |
| institution | Directory Open Access Journal |
| issn | 1740-4398 |
| language | English |
| last_indexed | 2024-03-08T18:35:22Z |
| publishDate | 2023-12-01 |
| publisher | BioExcel Publishing Ltd |
| record_format | Article |
| series | Drugs in Context |
| spelling | doaj.art-f78783fcedfa42df86d332695423703d2023-12-29T16:01:32ZengBioExcel Publishing LtdDrugs in Context1740-43982023-12-01121810.7573/dic.2023-6-5Diuretic resistance and the role of albumin in congestive heart failureCarol Fernandez HazimGustavo DuarteAna P UrenaSwati JainRishabh MishraTimothy J VittorioMiguel Rodriguez-GuerraDiuresis with loop diuretics is the mainstay treatment for volume optimization in patients with congestive heart failure, in which perfusion and volume expansion play a crucial role. There are robust guidelines with extensive evidence for the management of heart failure; however, clear guidance is needed for patients who do not respond to standard diuretic treatment. Diuretic resistance (DR) can be defined as an insufficient quantity of natriuresis with proper diuretic therapy. A combination of diuretic regimens is used to overcome DR and, more recently, SGLT2 inhibitors have been shown to improve diuresis. Despite DR being relatively common, it is challenging to treat and there remains a notable lack of substantial data guiding its management. Moreover, DR has been linked with poor prognosis. This review aims to expose the multiple approaches for treatment of patients with DR and the importance of intravascular volume expansion in the response to therapy.https://www.drugsincontext.com/diuretic-resistance-and-the-role-of-albumin-in-congestive-heart-failure/acetazolamidediuretic resistancefurosemideheart failureloop diureticspedal oedemasequential blockingsglt-2 inhibitorthiazidetorsemide |
| spellingShingle | Carol Fernandez Hazim Gustavo Duarte Ana P Urena Swati Jain Rishabh Mishra Timothy J Vittorio Miguel Rodriguez-Guerra Diuretic resistance and the role of albumin in congestive heart failure Drugs in Context acetazolamide diuretic resistance furosemide heart failure loop diuretics pedal oedema sequential blocking sglt-2 inhibitor thiazide torsemide |
| title | Diuretic resistance and the role of albumin in congestive heart failure |
| title_full | Diuretic resistance and the role of albumin in congestive heart failure |
| title_fullStr | Diuretic resistance and the role of albumin in congestive heart failure |
| title_full_unstemmed | Diuretic resistance and the role of albumin in congestive heart failure |
| title_short | Diuretic resistance and the role of albumin in congestive heart failure |
| title_sort | diuretic resistance and the role of albumin in congestive heart failure |
| topic | acetazolamide diuretic resistance furosemide heart failure loop diuretics pedal oedema sequential blocking sglt-2 inhibitor thiazide torsemide |
| url | https://www.drugsincontext.com/diuretic-resistance-and-the-role-of-albumin-in-congestive-heart-failure/ |
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