Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration
Alopecia: Stimulating hair growth via stem cell-based therapy A treatment developed using stem cells that express high levels of a hair-growth-stimulating protein could help treat alopecia. Cells at the base of hair follicles secrete signaling molecules that help maintain follicle stem cell populati...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-07-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-019-0266-7 |
| _version_ | 1818730708005289984 |
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| author | Junghyun Park Eun Kyoung Jun Daryeon Son Wonjun Hong Jihoon Jang Wonjin Yun Byung Sun Yoon Gwonhwa Song In Yong Kim Seungkwon You |
| author_facet | Junghyun Park Eun Kyoung Jun Daryeon Son Wonjun Hong Jihoon Jang Wonjin Yun Byung Sun Yoon Gwonhwa Song In Yong Kim Seungkwon You |
| author_sort | Junghyun Park |
| collection | DOAJ |
| description | Alopecia: Stimulating hair growth via stem cell-based therapy A treatment developed using stem cells that express high levels of a hair-growth-stimulating protein could help treat alopecia. Cells at the base of hair follicles secrete signaling molecules that help maintain follicle stem cell populations and stimulate hair growth, but defects in these signaling pathways can trigger alopecia. Potential treatments created using stem cells derived from amniotic fluid are being explored by Gwonhwa Song, In Yong Kim and Seungkwon You at the College of Life Sciences and Biotechnology, Seoul, South Korea. They have demonstrated that a protein called Nanog found in amniotic fluid-derived stem cell populations can help maintain stem cell health and stimulate secretion of hair growth proteins. These findings led them to develop a topical treatment with medicines derived from stem cells overexpressing Nanog, which triggered dermal cell proliferation and hair regrowth in mice. |
| first_indexed | 2024-12-17T23:06:04Z |
| format | Article |
| id | doaj.art-f788f942115c480aafc902731c389c91 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-17T23:06:04Z |
| publishDate | 2019-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-f788f942115c480aafc902731c389c912022-12-21T21:29:17ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-07-0151711510.1038/s12276-019-0266-7Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regenerationJunghyun Park0Eun Kyoung Jun1Daryeon Son2Wonjun Hong3Jihoon Jang4Wonjin Yun5Byung Sun Yoon6Gwonhwa Song7In Yong Kim8Seungkwon You9Department of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityInstitute of Regenerative Medicine, STEMLAB, Inc.Department of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityInstitute of Regenerative Medicine, STEMLAB, Inc.Department of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea UniversityAlopecia: Stimulating hair growth via stem cell-based therapy A treatment developed using stem cells that express high levels of a hair-growth-stimulating protein could help treat alopecia. Cells at the base of hair follicles secrete signaling molecules that help maintain follicle stem cell populations and stimulate hair growth, but defects in these signaling pathways can trigger alopecia. Potential treatments created using stem cells derived from amniotic fluid are being explored by Gwonhwa Song, In Yong Kim and Seungkwon You at the College of Life Sciences and Biotechnology, Seoul, South Korea. They have demonstrated that a protein called Nanog found in amniotic fluid-derived stem cell populations can help maintain stem cell health and stimulate secretion of hair growth proteins. These findings led them to develop a topical treatment with medicines derived from stem cells overexpressing Nanog, which triggered dermal cell proliferation and hair regrowth in mice.https://doi.org/10.1038/s12276-019-0266-7 |
| spellingShingle | Junghyun Park Eun Kyoung Jun Daryeon Son Wonjun Hong Jihoon Jang Wonjin Yun Byung Sun Yoon Gwonhwa Song In Yong Kim Seungkwon You Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration Experimental and Molecular Medicine |
| title | Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration |
| title_full | Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration |
| title_fullStr | Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration |
| title_full_unstemmed | Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration |
| title_short | Overexpression of Nanog in amniotic fluid–derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration |
| title_sort | overexpression of nanog in amniotic fluid derived mesenchymal stem cells accelerates dermal papilla cell activity and promotes hair follicle regeneration |
| url | https://doi.org/10.1038/s12276-019-0266-7 |
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